Derivation of a Human In Vivo Benchmark Dose for Perfluorooctanoic Acid From ToxCast In Vitro Concentration–Response Data Using a Computational Workflow for Probabilistic Quantitative In Vitro to In Vivo Extrapolation

A computational workflow which integrates physiologically based kinetic (PBK) modeling, global sensitivity analysis (GSA), approximate Bayesian computation (ABC), and Markov Chain Monte Carlo (MCMC) simulation was developed to facilitate quantitative in vitro to in vivo extrapolation (QIVIVE). The w...

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Detalles Bibliográficos
Autores principales: Loizou, George, McNally, Kevin, Dorne, Jean-Lou C. M., Hogg, Alex
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144460/
https://www.ncbi.nlm.nih.gov/pubmed/34045957
http://dx.doi.org/10.3389/fphar.2021.630457

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144460/
https://www.ncbi.nlm.nih.gov/pubmed/34045957
http://dx.doi.org/10.3389/fphar.2021.630457

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