Aberrant Synaptic PTEN in Symptomatic Alzheimer’s Patients May Link Synaptic Depression to Network Failure

In Alzheimer’s disease (AD), Amyloid β (Aβ) impairs synaptic function by inhibiting long-term potentiation (LTP), and by facilitating long-term depression (LTD). There is now evidence from AD models that Aβ provokes this shift toward synaptic depression by triggering the access to and accumulation o...

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Detalles Bibliográficos
Autores principales: Díaz González, Marta, Buberman, Assaf, Morales, Miguel, Ferrer, Isidro, Knafo, Shira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Synaptic Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144462/
https://www.ncbi.nlm.nih.gov/pubmed/34045952
http://dx.doi.org/10.3389/fnsyn.2021.683290

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144462/
https://www.ncbi.nlm.nih.gov/pubmed/34045952
http://dx.doi.org/10.3389/fnsyn.2021.683290

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