Identification of 2-(thiophen-2-yl)acetic Acid-Based Lead Compound for mPGES-1 Inhibition

We report the implementation of our in silico/synthesis pipeline by targeting the glutathione-dependent enzyme mPGES-1, a valuable macromolecular target in both cancer therapy and inflammation therapy. Specifically, by using a virtual fragment screening approach of aromatic bromides, straightforward...

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Detalles Bibliográficos
Autores principales: Di Micco, Simone, Terracciano, Stefania, Ruggiero, Dafne, Potenza, Marianna, Vaccaro, Maria C., Fischer, Katrin, Werz, Oliver, Bruno, Ines, Bifulco, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144515/
https://www.ncbi.nlm.nih.gov/pubmed/34046398
http://dx.doi.org/10.3389/fchem.2021.676631

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144515/
https://www.ncbi.nlm.nih.gov/pubmed/34046398
http://dx.doi.org/10.3389/fchem.2021.676631

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