Synthesis of multiply fluorinated N-acetyl-D-glucosamine and D-galactosamine analogs via the corresponding deoxyfluorinated glucosazide and galactosazide phenyl thioglycosides

Multiple fluorination of glycostructures has emerged as an attractive way of modulating their protein affinity, metabolic stability, and lipophilicity. Here we described the synthesis of a series of mono-, di- and trifluorinated N-acetyl-ᴅ-glucosamine and ᴅ-galactosamine analogs. The key intermediat...

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Detalles Bibliográficos
Autores principales: Hamala, Vojtěch, Červenková Šťastná, Lucie, Kurfiřt, Martin, Cuřínová, Petra, Dračínský, Martin, Karban, Jindřich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2021
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144920/
https://www.ncbi.nlm.nih.gov/pubmed/34093878
http://dx.doi.org/10.3762/bjoc.17.85

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144920/
https://www.ncbi.nlm.nih.gov/pubmed/34093878
http://dx.doi.org/10.3762/bjoc.17.85

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