SIRT1-Dependent Upregulation of BDNF in Human Microglia Challenged with Aβ: An Early but Transient Response Rescued by Melatonin

Microglia represent a first-line defense in the brain. However, in pathological conditions such as Alzheimer’s disease (AD), a pro-inflammatory switch may occur, leading to loss of protective functions. Using the human microglial cell line HMC3, we showed that exposure to low concentrations of β-amy...

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Detalles Bibliográficos
Autores principales: Caruso, Grazia Ilaria, Spampinato, Simona Federica, Costantino, Giuseppe, Merlo, Sara, Sortino, Maria Angela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8145207/
https://www.ncbi.nlm.nih.gov/pubmed/33923297
http://dx.doi.org/10.3390/biomedicines9050466

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8145207/
https://www.ncbi.nlm.nih.gov/pubmed/33923297
http://dx.doi.org/10.3390/biomedicines9050466

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