Inhibition of K-Ras4B-plasma membrane association with a membrane microdomain-targeting peptide

The association of K-Ras4B protein with plasma membrane (PM) is required for its signaling activity. Thus, direct inhibition of K-Ras4B–PM interaction could be a potential anti-Ras therapeutic strategy. However, it remains challenging to modulate such protein–PM interaction. Based on Ras isoform-spe...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Fang-Yi, Zhang, Zhen-Feng, Voss, Stephanie, Wu, Yao-Wen, Zhao, Yu-Fen, Li, Yan-Mei, Chen, Yong-Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8145430/
https://www.ncbi.nlm.nih.gov/pubmed/34123058
http://dx.doi.org/10.1039/c9sc04726c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8145430/
https://www.ncbi.nlm.nih.gov/pubmed/34123058
http://dx.doi.org/10.1039/c9sc04726c

Ejemplares similares