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Impact of rare and common genetic variation in the interleukin-1 pathway on human cytokine responses
BACKGROUND: The interleukin (IL)-1 pathway is primarily associated with innate immunological defense and plays a major role in the induction and regulation of inflammation. Both common and rare genetic variation in this pathway underlies various inflammation-mediated diseases, but the role of rare v...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8145796/ https://www.ncbi.nlm.nih.gov/pubmed/34034819 http://dx.doi.org/10.1186/s13073-021-00907-w |