Elevated Expression of Toxin TisB Protects Persister Cells against Ciprofloxacin but Enhances Susceptibility to Mitomycin C

Bacterial chromosomes harbor toxin-antitoxin (TA) systems, some of which are implicated in the formation of multidrug-tolerant persister cells. In Escherichia coli, toxin TisB from the tisB/istR-1 TA system depolarizes the inner membrane and causes ATP depletion, which presumably favors persister fo...

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Detalles Bibliográficos
Autores principales: Edelmann, Daniel, Leinberger, Florian H., Schmid, Nicole E., Oberpaul, Markus, Schäberle, Till F., Berghoff, Bork A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8145889/
https://www.ncbi.nlm.nih.gov/pubmed/33925723
http://dx.doi.org/10.3390/microorganisms9050943

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8145889/
https://www.ncbi.nlm.nih.gov/pubmed/33925723
http://dx.doi.org/10.3390/microorganisms9050943

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