Cargando…

Ectopic FOXP3 Expression in Combination with TGF-β1 and IL-2 Stimulation Generates Limited Suppressive Function in Human Primary Activated Thymocytes Ex Vivo

Regulatory T cells (Tregs), which are characterized by the expression of the transcription factor forkhead box P3 (FOXP3), are the main immune cells that induce tolerance and are regulators of immune homeostasis. Natural Treg cells (nTregs), described as CD4(+)CD25(+)FOXP3(+), are generated in the t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gallego-Valle, Jorge, Gil-Manso, Sergio, Pita, Ana, Bernaldo-de-Quirós, Esther, López-Esteban, Rocío, Martínez-Bonet, Marta, Pérez-Fernández, Verónica Astrid, Pérez-Caballero, Ramón, Pardo, Carlos, Gil-Jaurena, Juan-Miguel, Correa-Rocha, Rafael, Pion, Marjorie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146103/ https://www.ncbi.nlm.nih.gov/pubmed/33922629 http://dx.doi.org/10.3390/biomedicines9050461

Ejemplares similares

A Novel GMP Protocol to Produce High-Quality Treg Cells From the Pediatric Thymic Tissue to Be Employed as Cellular Therapy
por: Bernaldo-de-Quirós, Esther, et al.
Publicado: (2022)

Basiliximab impairs regulatory T cell (TREG) function and could affect the short-term graft acceptance in children with heart transplantation
por: López-Abente, Jacobo, et al.
Publicado: (2021)

A New Generation of Cell Therapies Employing Regulatory T Cells (Treg) to Induce Immune Tolerance in Pediatric Transplantation
por: Bernaldo-de-Quirós, Esther, et al.
Publicado: (2022)

Multidimensional analysis of immune cells from COVID-19 patients identified cell subsets associated with the severity at hospital admission
por: Gil-Manso, Sergio, et al.
Publicado: (2023)

The Presence of a Marked Imbalance Between Regulatory T Cells and Effector T Cells Reveals That Tolerance Mechanisms Could Be Compromised in Heart Transplant Children
por: Bernaldo-de-Quirós, Esther, et al.
Publicado: (2021)

Premature Expression of Foxp3 in Double-Negative Thymocytes
por: Barra, Melanie M., et al.
Publicado: (2015)

Hybrid Procedures. Opening Doors for Surgeon and Cardiologist Close Collaboration
por: Gil-Jaurena, Juan-Miguel, et al.
Publicado: (2021)

Clonal Bifurcation of Foxp3 Expression Visualized in Thymocytes and T Cells
por: Yen, Bonnie, et al.
Publicado: (2018)

Generation of Human Breg-Like Phenotype with Regulatory Function In Vitro with Bacteria-Derived Oligodeoxynucleotides
por: Gallego-Valle, Jorge, et al.
Publicado: (2018)

Orthotopic Heart Transplantation following univentricular palliation: new challenges for the congenital cardiac surgeon
por: González-López, María-Teresa, et al.
Publicado: (2015)

Modified Fontan conversion: an alternative technique for grown-up patients
por: González-López, María-Teresa, et al.
Publicado: (2015)

The thymic medulla is required for Foxp3(+) regulatory but not conventional CD4(+) thymocyte development
por: Cowan, Jennifer E., et al.
Publicado: (2013)

Aortopulmonary window due to transcatheter pulmonary valve implantation after arterial switch operation
por: González-López, María-Teresa, et al.
Publicado: (2015)

Comprehensive Flow Cytometry Profiling of the Immune System in COVID-19 Convalescent Individuals
por: Gil-Manso, Sergio, et al.
Publicado: (2022)

Cellular and Humoral Responses Follow-up for 8 Months after Vaccination with mRNA-Based Anti-SARS-CoV-2 Vaccines
por: Gil-Manso, Sergio, et al.
Publicado: (2022)

The frequency of CD25+CD4+ and FOXP3+ regulatory T cells in ectopic endometrium and ectopic decidua
por: Basta, Pawel, et al.
Publicado: (2010)

ABO blood group is involved in the quality of the specific immune response anti-SARS-CoV-2
por: Gil-Manso, Sergio, et al.
Publicado: (2021)

Selección de lo mejor del año 2021 en cardiopatías congénitas
por: Pijuan-Domenech, Antonia, et al.
Publicado: (2022)

Analysis of thymocyte MHC specificity with thymocyte hybridomas
Publicado: (1984)

IgG anti-RBD levels during 8-month follow-up post-vaccination with BNT162b2 and mRNA-1273 vaccines in healthcare workers: A one-center study
por: Gil-Manso, Sergio, et al.
Publicado: (2022)

Ex-Th17 Foxp3+ T cells - a novel subset of Foxp3+ T cells induced in cancer
por: Downs-Canner, Stephanie, et al.
Publicado: (2015)

Interleukin 4 inhibits TGF-β-induced-Foxp3(+)T cells and generates, in combination with TGF-β, Foxp3(−) effector T cells that produce interleukins 9 and 10
por: Dardalhon, Valérie, et al.
Publicado: (2008)

In Vivo Attenuation of Antibody-Mediated Acute Renal Allograft Rejection by Ex Vivo TGF-β-Induced CD4(+)Foxp3(+) Regulatory T Cells
por: Liao, Tao, et al.
Publicado: (2017)

Microcirculatory Differences in Children With Congenital Heart Disease According to Cyanosis and Age
por: González, Rafael, et al.
Publicado: (2019)

Molecular Mechanisms Regulating TGF-β-Induced Foxp3 Expression
por: Xu, Lili, et al.
Publicado: (2010)

Interleukin 4 promotes the development of ex-Foxp3 Th2 cells during immunity to intestinal helminths
por: Pelly, Victoria S., et al.
Publicado: (2017)

Defects in Thymocyte Differentiation and Thymocyte- Stromal Interactions in the Trisomy 16 Mouse
por: Ewart, Janet L., et al.
Publicado: (1992)

Induction of High Levels of Specific Humoral and Cellular Responses to SARS-CoV-2 After the Administration of Covid-19 mRNA Vaccines Requires Several Days
por: Gil-Manso, Sergio, et al.
Publicado: (2021)

Transfer of specific unresponsiveness to organ allografts by thymocytes. Specific unresponsiveness by thymocyte transfer
Publicado: (1979)

Patterns of Differentially Expressed circRNAs in Human Thymocytes
por: López-Nieva, Pilar, et al.
Publicado: (2022)

T cell receptor engagement by peptide–MHC ligands induces a conformational change in the CD3 complex of thymocytes
por: Gil, Diana, et al.
Publicado: (2005)

La información y el periodismo /
por: Torroba Bernaldo de Quirós, Felipe
Publicado: (1969)

Los judíos españoles
por: Torroba Bernaldo de Quirós, Felipe
Publicado: (1967)

La dislexia en la niñez
por: Quirós, Julio Benjamín Bernaldo de
Publicado: (1992)

Hepatopathy in an adult, secondary to congenital untreated panhypopituitarism and ectopic posterior pituitary gland
por: Valle-Murillo, Miguel A., et al.
Publicado: (2012)

Is thymocyte development functional in the aged?
por: Aw, Danielle, et al.
Publicado: (2009)

Lymphocyte subsets early predict mortality in a large series of hospitalized COVID‐19 patients in Spain
por: Cantenys‐Molina, S., et al.
Publicado: (2020)

FOXP3 expression is modulated by TGF-β1/NOTCH1 pathway in human melanoma
por: Skarmoutsou, Eva, et al.
Publicado: (2018)

Induction of stable human FOXP3(+) Tregs by a parasite‐derived TGF‐β mimic
por: Cook, Laura, et al.
Publicado: (2021)

Feminismo en el mundo global
por: Valcárcel y Bernaldo de Quirós, Amelia
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_8pr9f5f2rbvtb5lvjsokrpuvc1