Discovery of New Small Molecule Hits as Hepatitis B Virus Capsid Assembly Modulators: Structure and Pharmacophore-Based Approaches

Hepatitis B virus (HBV) capsid assembly modulators (CpAMs) have shown promise as potent anti-HBV agents in both preclinical and clinical studies. Herein, we report our efforts in identifying novel CpAM hits via a structure-based virtual screening against a small molecule protein-protein interaction...

Descripción completa

Detalles Bibliográficos
Autores principales: Senaweera, Sameera, Du, Haijuan, Zhang, Huanchun, Kirby, Karen A., Tedbury, Philip R., Xie, Jiashu, Sarafianos, Stefan G., Wang, Zhengqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146408/
https://www.ncbi.nlm.nih.gov/pubmed/33925540
http://dx.doi.org/10.3390/v13050770

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146408/
https://www.ncbi.nlm.nih.gov/pubmed/33925540
http://dx.doi.org/10.3390/v13050770

Ejemplares similares