Mutations and Protein Interaction Landscape Reveal Key Cellular Events Perturbed in Upper Motor Neurons with HSP and PLS

Hereditary spastic paraplegia (HSP) and primary lateral sclerosis (PLS) are rare motor neuron diseases, which affect mostly the upper motor neurons (UMNs) in patients. The UMNs display early vulnerability and progressive degeneration, while other cortical neurons mostly remain functional. Identifica...

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Detalles Bibliográficos
Autores principales: Gozutok, Oge, Helmold, Benjamin Ryan, Ozdinler, P. Hande
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146506/
https://www.ncbi.nlm.nih.gov/pubmed/33947096
http://dx.doi.org/10.3390/brainsci11050578

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146506/
https://www.ncbi.nlm.nih.gov/pubmed/33947096
http://dx.doi.org/10.3390/brainsci11050578

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