Enhanced Bioavailability and Efficacy of Silymarin Solid Dispersion in Rats with Acetaminophen-Induced Hepatotoxicity

We evaluated the bioavailability, liver distribution, and efficacy of silymarin-D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) solid dispersion (silymarin-SD) in rats with acetaminophen-induced hepatotoxicity (APAP) compared with silymarin alone. The solubility of silybin, the major and ac...

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Detalles Bibliográficos
Autores principales: Song, Im-Sook, Nam, So-Jeong, Jeon, Ji-Hyeon, Park, Soo-Jin, Choi, Min-Koo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146637/
https://www.ncbi.nlm.nih.gov/pubmed/33925040
http://dx.doi.org/10.3390/pharmaceutics13050628

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146637/
https://www.ncbi.nlm.nih.gov/pubmed/33925040
http://dx.doi.org/10.3390/pharmaceutics13050628

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