Cargando…

Enhanced Bioavailability and Efficacy of Silymarin Solid Dispersion in Rats with Acetaminophen-Induced Hepatotoxicity

We evaluated the bioavailability, liver distribution, and efficacy of silymarin-D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) solid dispersion (silymarin-SD) in rats with acetaminophen-induced hepatotoxicity (APAP) compared with silymarin alone. The solubility of silybin, the major and ac...

Descripción completa

Detalles Bibliográficos
Autores principales:	Song, Im-Sook, Nam, So-Jeong, Jeon, Ji-Hyeon, Park, Soo-Jin, Choi, Min-Koo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146637/ https://www.ncbi.nlm.nih.gov/pubmed/33925040 http://dx.doi.org/10.3390/pharmaceutics13050628

Ejemplares similares

Silymarin prevents acetaminophen-induced hepatotoxicity in mice
por: Papackova, Zuzana, et al.
Publicado: (2018)

Hepatoprotective Effect of Silymarin (Silybum marianum) on Hepatotoxicity Induced by Acetaminophen in Spontaneously Hypertensive Rats
por: Freitag, Abel Felipe, et al.
Publicado: (2015)

Improved Hygroscopicity and Bioavailability of Solid Dispersion of Red Ginseng Extract with Silicon Dioxide
por: Jin, Sojeong, et al.
Publicado: (2021)

Hepatoprotective Actions of Ascorbic Acid, Alpha Lipoic Acid and Silymarin or Their Combination Against Acetaminophen-Induced Hepatotoxicity in Rats
por: Abdulrazzaq, Anmar M., et al.
Publicado: (2019)

Silymarin nanoparticle prevents paracetamol-induced hepatotoxicity
por: Das, Suvadra, et al.
Publicado: (2011)

Protective Effects of Garlic and Silymarin on NDEA-Induced Rats Hepatotoxicity
por: Shaarawy, Sabry M, et al.
Publicado: (2009)

Protective effects of silymarin on triptolide-induced acute hepatotoxicity in rats
por: Wang, Lan, et al.
Publicado: (2018)

Acetaminophen-induced Hepato- and Nephrotoxicity and Amelioration by Silymarin and Terminalia chebula in Rats
por: Gopi, K. S., et al.
Publicado: (2010)

Effect of Prophylactic Use of Silymarin on Anti-tuberculosis Drugs Induced Hepatotoxicity
por: Heo, Eunyoung, et al.
Publicado: (2017)

Impact of malnourishment on the pharmacokinetics of acetaminophen and susceptibility to acetaminophen hepatotoxicity
por: Zillen, Daan, et al.
Publicado: (2021)

Protective effect of rutin in comparison to silymarin against induced hepatotoxicity in rats
por: Reddy, M. Kasi, et al.
Publicado: (2017)

The Protective Effects of Silymarin against Doxorubicin-Induced Cardiotoxicity and Hepatotoxicity in Rats
por: Rašković, Aleksandar, et al.
Publicado: (2011)

Atorvastatin solid dispersion for bioavailability enhancement
por: Shamsuddin,, et al.
Publicado: (2016)

Modulatory Effects of Silymarin on Benzo[a]pyrene-Induced Hepatotoxicity
por: Jee, Seung-Cheol, et al.
Publicado: (2020)

Acetaminophen Induced Hepatotoxicity in Wistar Rats—A Proteomic Approach
por: Ilavenil, Soundharrajan, et al.
Publicado: (2016)

Formulation Strategies for Enhancing the Bioavailability of Silymarin: The State of the Art
por: Di Costanzo, Alfonso, et al.
Publicado: (2019)

Mitochondrial–Lysosomal Axis in Acetaminophen Hepatotoxicity
por: Moles, Anna, et al.
Publicado: (2018)

Role of Pyroptosis in Acetaminophen-Induced Hepatotoxicity
por: Jaeschke, Hartmut, et al.
Publicado: (2022)

Regeneration and Recovery after Acetaminophen Hepatotoxicity
por: Bhushan, Bharat, et al.
Publicado: (2023)

Protective Effects of Apamin on Acetaminophen-Induced Hepatotoxicity in Mice
por: Jang, Hyo-Jeong, et al.
Publicado: (2023)

Acetaminophen Hepatotoxicity: Not as Simple as One Might Think! Introductory Comments on the Special Issue—Recent Advances in Acetaminophen Hepatotoxicity
por: Jaeschke, Hartmut
Publicado: (2022)

Fructose diet alleviates acetaminophen-induced hepatotoxicity in mice
por: Cho, Sungjoon, et al.
Publicado: (2017)

Phenylpropionic acid produced by gut microbiota alleviates acetaminophen-induced hepatotoxicity
por: Cho, Sungjoon, et al.
Publicado: (2023)

Protective effects of silymarin on fumonisin B(1)-induced hepatotoxicity in mice
por: Sozmen, Mahmut, et al.
Publicado: (2014)

Synthesis, characterization and hepatoprotective effect of silymarin phytosome nanoparticles on ethanol-induced hepatotoxicity in rats
por: Gohari Mahmoudabad, Arezoo, et al.
Publicado: (2023)

Effect of amlodipine, lisinopril and allopurinol on acetaminophen-induced hepatotoxicity in rats
por: Mohammed, Nesreen E.M., et al.
Publicado: (2016)

Characteristics and Outcomes of Acetaminophen Overdose and Hepatotoxicity in Thailand
por: Pholmoo, Natthiya, et al.
Publicado: (2019)

Mechanisms of acetaminophen hepatotoxicity and their translation to the human pathophysiology
por: Ramachandran, Anup, et al.
Publicado: (2017)

Acetaminophen-Induced Hepatotoxicity: a Comprehensive Update
por: Yoon, Eric, et al.
Publicado: (2016)

Possible Role of Extracellular Vesicles in Hepatotoxicity of Acetaminophen
por: Šrajer Gajdošik, Martina, et al.
Publicado: (2022)

Fluorine-thiol displacement probes for acetaminophen's hepatotoxicity
por: Prather, Benjamin L., et al.
Publicado: (2023)

Hepatoprotective Property of Oral Silymarin is Comparable to N-Acetyl Cysteine in Acetaminophen Poisoning
por: Kazemifar, Amir Mohammad, et al.
Publicado: (2012)

Efficacy of free glutathione and niosomal glutathione in the treatment of acetaminophen-induced hepatotoxicity in cats
por: Vulcano, L.A. Denzoin, et al.
Publicado: (2013)

Evaluation of the bioavailability of hydrocortisone when prepared as solid dispersion
por: Altamimi, Mohammad A., et al.
Publicado: (2019)

PYP1-4 peptide from Pyropia yezoensis protects against acetaminophen-induced hepatotoxicity in HepG2 cells
por: Kim, In-Hye, et al.
Publicado: (2020)

Protective effects of silymarin against bisphenol A-induced hepatotoxicity in mouse liver
por: Zaulet, Mihaela, et al.
Publicado: (2017)

Protective Effect of Silymarin and Gallic Acid against Cisplatin-Induced Nephrotoxicity and Hepatotoxicity
por: Doğan, Duygu, et al.
Publicado: (2022)

Hepatocyte-Specific Deficiency of DAX-1 Protects Mice from Acetaminophen-Induced Hepatotoxicity by Activating NRF2 Signaling
por: Suh, Young-Joo, et al.
Publicado: (2022)

Cefdinir Solid Dispersion Composed of Hydrophilic Polymers with Enhanced Solubility, Dissolution, and Bioavailability in Rats
por: Cho, Hyun-Jong, et al.
Publicado: (2017)

The Bioavailability and Pharmacokinetics of Silymarin SMEDDS Formulation Study in Healthy Thai Volunteers
por: Sornsuvit, Chuleegone, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_dddppie3hm2h1rukm885qogi0d