Therapeutic Approach of KRAS Mutant Tumours by the Combination of Pharmacologic Ascorbate and Chloroquine

The Warburg effect has been considered a potential therapeutic target to fight against cancer progression. In KRAS mutant cells, PKM2 (pyruvate kinase isozyme M2) is hyper-activated, and it induces GLUT1 expression; therefore, KRAS has been closely involved in the initiation of Warburg metabolism. A...

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Detalles Bibliográficos
Autores principales: Kapuy, Orsolya, Makk-Merczel, Kinga, Szarka, András
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146763/
https://www.ncbi.nlm.nih.gov/pubmed/33925206
http://dx.doi.org/10.3390/biom11050652

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146763/
https://www.ncbi.nlm.nih.gov/pubmed/33925206
http://dx.doi.org/10.3390/biom11050652

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