Establishment, Validation, and Initial Application of a Sensitive LC-MS/MS Assay for Quantification of the Naturally Occurring Isomers Itaconate, Mesaconate, and Citraconate

Itaconate is derived from the tricarboxylic acid (TCA) cycle intermediate cis-aconitate and links innate immunity and metabolism. Its synthesis is altered in inflammation-related disorders and it therefore has potential as clinical biomarker. Mesaconate and citraconate are naturally occurring isomer...

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Detalles Bibliográficos
Autores principales: Winterhoff, Moritz, Chen, Fangfang, Sahini, Nishika, Ebensen, Thomas, Kuhn, Maike, Kaever, Volkhard, Bähre, Heike, Pessler, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146994/
https://www.ncbi.nlm.nih.gov/pubmed/33925995
http://dx.doi.org/10.3390/metabo11050270

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146994/
https://www.ncbi.nlm.nih.gov/pubmed/33925995
http://dx.doi.org/10.3390/metabo11050270

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