Cargando…

Targeting Bacterial Sortases in Search of Anti-virulence Therapies with Low Risk of Resistance Development

Increasingly ineffective antibiotics and rapid spread of multi- and pan-resistant bacteria represent a global health threat; hence, the need of developing new antimicrobial medicines. A first step in this direction is identifying new molecular targets, such as virulence factors. Sortase A represents...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nitulescu, Georgiana, Margina, Denisa, Zanfirescu, Anca, Olaru, Octavian Tudorel, Nitulescu, George Mihai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147154/ https://www.ncbi.nlm.nih.gov/pubmed/33946434 http://dx.doi.org/10.3390/ph14050415

Ejemplares similares

Structural Analysis of Sortase A Inhibitors
por: Nitulescu, Georgiana, et al.
Publicado: (2016)

Molecular Docking and Screening Studies of New Natural Sortase A Inhibitors
por: Nitulescu, Georgiana, et al.
Publicado: (2017)

Cetirizine and Levetiracetam as Inhibitors of Monoacylglycerol Lipase: Investigating Their Repurposing Potential as Novel Osteoarthritic Pain Therapies
por: Andrei, Corina, et al.
Publicado: (2023)

Predictive power of the Triticum root elongation test for the assessment of novel anti-proliferative therapies
por: Olaru, Octavian Tudorel, et al.
Publicado: (2019)

Vitamin E beyond Its Antioxidant Label
por: Ungurianu, Anca, et al.
Publicado: (2021)

Natural Active Ingredients and TRPV1 Modulation: Focus on Key Chemical Moieties Involved in Ligand–Target Interaction
por: Andrei, Corina, et al.
Publicado: (2023)

Identification of Novel Antistaphylococcal Hit Compounds Targeting Sortase A
por: Volynets, Galyna, et al.
Publicado: (2021)

Candidates for Repurposing as Anti-Virulence Agents Based on the Structural Profile Analysis of Microbial Collagenase Inhibitors
por: Nitulescu, Georgiana, et al.
Publicado: (2021)

The Akt pathway in oncology therapy and beyond (Review)
por: Nitulescu, George Mihai, et al.
Publicado: (2018)

Identifying FAAH Inhibitors as New Therapeutic Options for the Treatment of Chronic Pain through Drug Repurposing
por: Zanfirescu, Anca, et al.
Publicado: (2021)

New Potential Antitumor Pyrazole Derivatives: Synthesis and Cytotoxic Evaluation
por: Nitulescu, George Mihai, et al.
Publicado: (2013)

Improving the odds of success in antitumoral drug development using scoring approaches towards heterocyclic scaffolds
por: Ion, George Nicolae Daniel, et al.
Publicado: (2020)

In Vitro Anti-proliferative Activity and Mechanism of Action of Anemone nemorosa
por: Swanepoel, Bresler, et al.
Publicado: (2019)

Discovery of New Microbial Collagenase Inhibitors
por: Nitulescu, Georgiana, et al.
Publicado: (2022)

Akt inhibitors in cancer treatment: The long journey from drug discovery to clinical use (Review)
por: NITULESCU, GEORGE MIHAI, et al.
Publicado: (2015)

The Importance of the Pyrazole Scaffold in the Design of Protein Kinases Inhibitors as Targeted Anticancer Therapies
por: Nitulescu, George Mihai, et al.
Publicado: (2023)

Anti-Cancer Activity of a 5-Aminopyrazole Derivative Lead Compound (BC-7) and Potential Synergistic Cytotoxicity with Cisplatin against Human Cervical Cancer Cells
por: Swanepoel, Bresler, et al.
Publicado: (2019)

Biopharmaceutical Profiling of New Antitumor Pyrazole Derivatives
por: Anuta, Valentina, et al.
Publicado: (2014)

Ethnomedicinal, Phytochemical and Pharmacological Profile of Anthriscus sylvestris as an Alternative Source for Anticancer Lignans
por: Olaru, Octavian Tudorel, et al.
Publicado: (2015)

Resveratrol and Other Natural Oligomeric Stilbenoid Compounds and Their Therapeutic Applications
por: Duta-Bratu, Cosmina-Gabriela, et al.
Publicado: (2023)

Effects of Venlafaxine, Risperidone and Febuxostat on Cuprizone-Induced Demyelination, Behavioral Deficits and Oxidative Stress
por: Mihai, Dragos Paul, et al.
Publicado: (2021)

HIV-1 integrase inhibitors targeting various DDE transposases: Retroviral integration versus RAG-mediated recombination
por: Mușat, Mihaela Georgiana, et al.
Publicado: (2019)

Targeting Monoacylglycerol Lipase in Pursuit of Therapies for Neurological and Neurodegenerative Diseases
por: Zanfirescu, Anca, et al.
Publicado: (2021)

In Silico Drug Repurposing Framework Predicts Repaglinide, Agomelatine and Protokylol as TRPV1 Modulators with Analgesic Activity
por: Andrei, Corina, et al.
Publicado: (2022)

Synthesis and Anticancer Evaluation of New 1,3,4-Oxadiazole Derivatives
por: Stecoza, Camelia Elena, et al.
Publicado: (2021)

Toxicity of plant extracts containing pyrrolizidine alkaloids using alternative invertebrate models
por: Seremet, Oana Cristina, et al.
Publicado: (2018)

Regulation of Gene Expression through Food—Curcumin as a Sirtuin Activity Modulator
por: Ungurianu, Anca, et al.
Publicado: (2022)

Chronic Monosodium Glutamate Administration Induced Hyperalgesia in Mice
por: Zanfirescu, Anca, et al.
Publicado: (2017)

Synthesis and Toxicity Evaluation of New Pyrroles Obtained by the Reaction of Activated Alkynes with 1-Methyl-3-(cyanomethyl)benzimidazolium Bromide
por: Ivan, Beatrice-Cristina, et al.
Publicado: (2021)

In Search of Outliers. Mining for Protein Kinase Inhibitors Based on Their Anti-Proliferative NCI-60 Cell Lines Profile
por: Ion, George Nicolae Daniel, et al.
Publicado: (2020)

Assessment of the potential health benefits of certain total extracts from Vitis vinifera, Aesculus hyppocastanum and Curcuma longa
por: MARGINĂ, DENISA, et al.
Publicado: (2015)

Quantitative and Qualitative Analysis of the Anti-Proliferative Potential of the Pyrazole Scaffold in the Design of Anticancer Agents
por: Nitulescu, George Mihai
Publicado: (2022)

Synthesis, In Silico and In Vitro Evaluation of Antimicrobial and Toxicity Features of New 4-[(4-Chlorophenyl)sulfonyl]benzoic Acid Derivatives
por: Apostol, Theodora-Venera, et al.
Publicado: (2021)

Synthesis and Biological Evaluation of New N-Acyl-α-amino Ketones and 1,3-Oxazoles Derivatives
por: Apostol, Theodora-Venera, et al.
Publicado: (2021)

Overview of the effects of chemical mixtures with endocrine disrupting activity in the context of real-life risk simulation: An integrative approach (Review)
por: MARGINA, DENISA, et al.
Publicado: (2019)

Analysis of the intricate effects of polyunsaturated fatty acids and polyphenols on inflammatory pathways in health and disease
por: Margină, Denisa, et al.
Publicado: (2020)

The Polyphenolic Profile and Antioxidant Activity of Five Vegetal Extracts with Hepatoprotective Potential
por: Costea, Liliana, et al.
Publicado: (2022)

Synthesis, Characterization and Cytotoxic Evaluation of New Pyrrolo[1,2-b]pyridazines Obtained via Mesoionic Oxazolo-Pyridazinones
por: Ivan, Beatrice-Cristina, et al.
Publicado: (2023)

New Pyrrole Derivatives as Promising Biological Agents: Design, Synthesis, Characterization, In Silico, and Cytotoxicity Evaluation
por: Ivan, Beatrice-Cristina, et al.
Publicado: (2022)

New Heterocyclic Compounds from Oxazol-5(4H)-one and 1,2,4-Triazin-6(5H)-one Classes: Synthesis, Characterization and Toxicity Evaluation
por: Barbuceanu, Stefania-Felicia, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_sdfks3ivh7j8dhi72di3m7vf42