CD8(+) T cell self-tolerance permits responsiveness but limits tissue damage

Self-specific CD8(+)T cells can escape clonal deletion, but the properties and capabilities of such cells in a physiological setting are unclear. We characterized polyclonal CD8(+) T cells specific for the melanocyte antigen tyrosinase-related protein 2 (Trp2) in mice expressing or lacking this enzy...

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Detalles Bibliográficos
Autores principales: Truckenbrod, Emily N, Burrack, Kristina S, Knutson, Todd P, Borges da Silva, Henrique, Block, Katharine E, O'Flanagan, Stephen D, Stagliano, Katie R, Hurwitz, Arthur A, Fulton, Ross B, Renkema, Kristin R, Jameson, Stephen C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147182/
https://www.ncbi.nlm.nih.gov/pubmed/33929324
http://dx.doi.org/10.7554/eLife.65615

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147182/
https://www.ncbi.nlm.nih.gov/pubmed/33929324
http://dx.doi.org/10.7554/eLife.65615

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