Design, Synthesis, and Molecular Docking Study of New Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Inhibitors Combining Resin Acids and Adamantane Moieties

In this paper, a series of novel abietyl and dehydroabietyl ureas, thioureas, amides, and thioamides bearing adamantane moieties were designed, synthesized, and evaluated for their inhibitory activities against tyrosil-DNA-phosphodiesterase 1 (TDP1). The synthesized compounds were able to inhibit TD...

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Detalles Bibliográficos
Autores principales: Kovaleva, Kseniya, Yarovaya, Olga, Ponomarev, Konstantin, Cheresiz, Sergey, Azimirad, Amirhossein, Chernyshova, Irina, Zakharenko, Alexandra, Konev, Vasily, Khlebnikova, Tatiana, Mozhaytsev, Evgenii, Suslov, Evgenii, Nilov, Dmitry, Švedas, Vytas, Pokrovsky, Andrey, Lavrik, Olga, Salakhutdinov, Nariman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147275/
https://www.ncbi.nlm.nih.gov/pubmed/34062881
http://dx.doi.org/10.3390/ph14050422

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147275/
https://www.ncbi.nlm.nih.gov/pubmed/34062881
http://dx.doi.org/10.3390/ph14050422

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