Vaccination by Two DerG LEAPS Conjugates Incorporating Distinct Proteoglycan (PG, Aggrecan) Epitopes Provides Therapy by Different Immune Mechanisms in a Mouse Model of Rheumatoid Arthritis

Rheumatoid arthritis (RA) can be initiated and driven by immune responses to multiple antigenic epitopes including those in cartilage proteoglycan (PG, aggrecan) and type II collagen. RA is driven by T helper 1 (Th1) or Th17 pro-inflammatory T cell responses. LEAPS (Ligand Epitope Antigen Presentati...

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Detalles Bibliográficos
Autores principales: Zimmerman, Daniel H., Mikecz, Katalin, Markovics, Adrienn, Carambula, Roy E., Ciemielewski, Jason C., Toth, Daniel M., Glant, Tibor T., Rosenthal, Ken S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147650/
https://www.ncbi.nlm.nih.gov/pubmed/34063326
http://dx.doi.org/10.3390/vaccines9050448

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147650/
https://www.ncbi.nlm.nih.gov/pubmed/34063326
http://dx.doi.org/10.3390/vaccines9050448

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