Cargando…

Vaccination by Two DerG LEAPS Conjugates Incorporating Distinct Proteoglycan (PG, Aggrecan) Epitopes Provides Therapy by Different Immune Mechanisms in a Mouse Model of Rheumatoid Arthritis

Rheumatoid arthritis (RA) can be initiated and driven by immune responses to multiple antigenic epitopes including those in cartilage proteoglycan (PG, aggrecan) and type II collagen. RA is driven by T helper 1 (Th1) or Th17 pro-inflammatory T cell responses. LEAPS (Ligand Epitope Antigen Presentati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zimmerman, Daniel H., Mikecz, Katalin, Markovics, Adrienn, Carambula, Roy E., Ciemielewski, Jason C., Toth, Daniel M., Glant, Tibor T., Rosenthal, Ken S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147650/ https://www.ncbi.nlm.nih.gov/pubmed/34063326 http://dx.doi.org/10.3390/vaccines9050448

Ejemplares similares

Immune Recognition of Citrullinated Proteoglycan Aggrecan Epitopes in Mice with Proteoglycan-Induced Arthritis and in Patients with Rheumatoid Arthritis
por: Markovics, Adrienn, et al.
Publicado: (2016)

Characterization and Localization of Citrullinated Proteoglycan Aggrecan in Human Articular Cartilage
por: Glant, Tibor T., et al.
Publicado: (2016)

Restoring the Balance between Pro-Inflammatory and Anti-Inflammatory Cytokines in the Treatment of Rheumatoid Arthritis: New Insights from Animal Models
por: Markovics, Adrienn, et al.
Publicado: (2021)

Regulation of autoimmune arthritis by the SHP-1 tyrosine phosphatase
por: Markovics, Adrienn, et al.
Publicado: (2020)

Proteoglycan Aggrecan Conducting T Cell Activation and Apoptosis in a Murine Model of Rheumatoid Arthritis
por: Hanyecz, A., et al.
Publicado: (2014)

Development of proteoglycan-induced arthritis depends on T cell-supported autoantibody production, but does not involve significant influx of T cells into the joints
por: Angyal, Adrienn, et al.
Publicado: (2010)

Th1 and Th2 cytokines regulate proteoglycan-specific autoantibody isotypes and arthritis
por: Kaplan, Charles, et al.
Publicado: (2002)

Suppression of Proteoglycan-Induced Autoimmune Arthritis by Myeloid-Derived Suppressor Cells Generated In Vitro from Murine Bone Marrow
por: Kurkó, Júlia, et al.
Publicado: (2014)

Epigenetics in the pathogenesis of rheumatoid arthritis
por: Glant, Tibor T, et al.
Publicado: (2014)

J‐LEAPS peptide and LEAPS dendritic cell vaccines
por: Rosenthal, Ken S., et al.
Publicado: (2012)

LEAPS Vaccine Incorporating HER-2/neu Epitope Elicits Protection That Prevents and Limits Tumor Growth and Spread of Breast Cancer in a Mouse Model
por: Rosenthal, Ken S., et al.
Publicado: (2017)

BALB/c mice genetically susceptible to proteoglycan-induced arthritis and spondylitis show colony-dependent differences in disease penetrance
por: Farkas, Balint, et al.
Publicado: (2009)

T(h)1/T(h)17 polarization and acquisition of an arthritogenic phenotype in arthritis-susceptible BALB/c, but not in MHC-matched, arthritis-resistant DBA/2 mice
por: Boldizsar, Ferenc, et al.
Publicado: (2009)

Age-related changes in arthritis susceptibility and severity in a murine model of rheumatoid arthritis
por: Tarjanyi, Oktavia, et al.
Publicado: (2009)

Enigma of IL-17 and Th17 Cells in Rheumatoid Arthritis and in Autoimmune Animal Models of Arthritis
por: Kugyelka, Reka, et al.
Publicado: (2016)

Inhibition of indoleamine 2,3-dioxygenase-mediated tryptophan catabolism accelerates collagen-induced arthritis in mice
por: Szántó, Sándor, et al.
Publicado: (2007)

Testing if Micro-CT Is Capable of Quantitating the Extent of Proteoglycan-Aggrecan Induced Axial Spondyloarthritis in Mice
por: Han, Qing, et al.
Publicado: (2021)

Gene expression profiling in murine autoimmune arthritis during the initiation and progression of joint inflammation
por: Adarichev, Vyacheslav A, et al.
Publicado: (2005)

Aggrecan, the Primary Weight-Bearing Cartilage Proteoglycan, Has Context-Dependent, Cell-Directive Properties in Embryonic Development and Neurogenesis: Aggrecan Glycan Side Chain Modifications Convey Interactive Biodiversity
por: Hayes, Anthony J, et al.
Publicado: (2020)

Non-MHC Risk Alleles in Rheumatoid Arthritis and in the Syntenic Chromosome Regions of Corresponding Animal Models
por: Besenyei, Timea, et al.
Publicado: (2012)

GRB2 promotes thymocyte positive selection by facilitating THEMIS-mediated inactivation of SHP1
por: Choi, Seeyoung, et al.
Publicado: (2023)

Identification of myeloid-derived suppressor cells in the synovial fluid of patients with rheumatoid arthritis: a pilot study
por: Kurkó, Júlia, et al.
Publicado: (2014)

Sphingosine-1-phosphate attenuates proteoglycan aggrecan expression via production of prostaglandin E(2 )from human articular chondrocytes
por: Masuko, Kayo, et al.
Publicado: (2007)

Structural comparison of somatically related PG9 and PG16 in complex with their epitope reveals differences in glycan recognition
por: Pancera, M, et al.
Publicado: (2012)

Early anti-inflammatory intervention ameliorates axial disease in the proteoglycan-induced spondylitis mouse model of ankylosing spondylitis
por: Tseng, Hsu-Wen, et al.
Publicado: (2017)

P04-51 LB. The epitopes of two newly identified broad and potent neutralizing antibodies, PG9 and PG16
por: Walker, L, et al.
Publicado: (2009)

Expression Pattern of Tenascin-C, Matrilin-2, and Aggrecan in Diseases Affecting the Corneal Endothelium
por: Varkoly, Gréta, et al.
Publicado: (2022)

Cross-group neutralization of HIV-1 and evidence for conservation of the PG9/PG16 epitopes within divergent groups of HIV-1
por: Braibant, M, et al.
Publicado: (2012)

The role of aggrecan in normal and osteoarthritic cartilage
por: Roughley, Peter J, et al.
Publicado: (2014)

Regulatory role of capsaicin-sensitive peptidergic sensory nerves in the proteoglycan-induced autoimmune arthritis model of the mouse
por: Horváth, Ádám, et al.
Publicado: (2018)

IL-10 Is Critically Involved in Mycobacterial HSP70 Induced Suppression of Proteoglycan-Induced Arthritis
por: Wieten, Lotte, et al.
Publicado: (2009)

Nicotinic acid suppresses sebaceous lipogenesis of human sebocytes via activating hydroxycarboxylic acid receptor 2 (HCA(2))
por: Markovics, Arnold, et al.
Publicado: (2019)

Aggrecan heterogeneity in articular cartilage from patients with osteoarthritis
por: Mort, John S., et al.
Publicado: (2016)

Laboratory Indicators of Aggrecan Turnover in Juvenile Idiopathic Arthritis
por: Winsz-Szczotka, Katarzyna, et al.
Publicado: (2016)

Juvenile Hippocampal CA2 Region Expresses Aggrecan
por: Noguchi, Asako, et al.
Publicado: (2017)

LEAP LEAR
Publicado: (1996)

Leaps in genetics
por: Damle, S. G.
Publicado: (2010)

Quantum leaps
por: Bernstein, Jeremy
Publicado: (2009)

Protective Role of the PG1036-PG1037-PG1038 Operon in Oxidative Stress in Porphyromonas gingivalis W83
por: Henry, Leroy G., et al.
Publicado: (2013)

Patients with rheumatoid arthritis have an altered circulatory aggrecan profile
por: Rousseau, Jean C, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_hv5g8gr3sauoe29le25v5slicm