HDAC8 Activates AKT through Upregulating PLCB1 and Suppressing DESC1 Expression in MEK1/2 Inhibition-Resistant Cells

Inhibition of the RAF-MEK1/2-ERK signaling pathway is an ideal strategy for treating cancers with NRAS or BRAF mutations. However, the development of resistance due to incomplete inhibition of the pathway and activation of compensatory cell proliferation pathways is a major impediment of the targete...

Descripción completa

Detalles Bibliográficos
Autores principales: Ha, Soon-Duck, Lewin, Naomi, Li, Shawn S. C., Kim, Sung-Ouk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147860/
https://www.ncbi.nlm.nih.gov/pubmed/34064422
http://dx.doi.org/10.3390/cells10051101

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147860/
https://www.ncbi.nlm.nih.gov/pubmed/34064422
http://dx.doi.org/10.3390/cells10051101

Ejemplares similares