Cargando…

Automated Sequential Analysis of Hydrophilic and Lipophilic Fractions of Biological Samples: Increasing Single-Injection Chemical Coverage in Untargeted Metabolomics

In order to increase metabolite coverage in LC–MS-based untargeted metabolomics, HILIC- and RPLC-mode separations are often combined. Unfortunately, these two techniques pose opposite requirements on sample composition, necessitating either dual sample preparations, increasing needed sample volume,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pirttilä, Kristian, Laurell, Göran, Pettersson, Curt, Hedeland, Mikael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147996/ https://www.ncbi.nlm.nih.gov/pubmed/34063084 http://dx.doi.org/10.3390/metabo11050295

Ejemplares similares

An LCMS-based untargeted metabolomics protocol for cochlear perilymph: highlighting metabolic effects of hydrogen gas on the inner ear of noise exposed Guinea pigs
por: Pirttilä, Kristian, et al.
Publicado: (2019)

Comprehensive Peak Characterization (CPC) in Untargeted LC–MS Analysis
por: Pirttilä, Kristian, et al.
Publicado: (2022)

Improved Sensitivity in Hydrophilic Interaction Liquid Chromatography-Electrospray-Mass Spectrometry after Removal of Sodium and Potassium Ions from Biological Samples
por: Erngren, Ida, et al.
Publicado: (2021)

Hydrophilic or Lipophilic Statins?
por: Climent, Elisenda, et al.
Publicado: (2021)

Hydrogen Inhalation Protects against Ototoxicity Induced by Intravenous Cisplatin in the Guinea Pig
por: Fransson, Anette E., et al.
Publicado: (2017)

Highly Hydrophilic and Lipophilic Derivatives of Bile Salts
por: Vázquez-Tato, M. Pilar, et al.
Publicado: (2021)

Investigation of neomycin biodegradation conditions using ericoid mycorrhizal and white rot fungal species
por: Stenholm, Åke, et al.
Publicado: (2022)

Preparation and Hydrophilicity/Lipophilicity of Solubility-Switchable Ionic Liquids
por: Kamimura, Akio, et al.
Publicado: (2022)

Exploring Radiation Response in Two Head and Neck Squamous Carcinoma Cell Lines Through Metabolic Profiling
por: Lindell Jonsson, Eva, et al.
Publicado: (2019)

Permeability of Red Cell Membranes to Small Hydrophilic and Lipophilic Solutes
por: Sha'afi, R. I., et al.
Publicado: (1971)

Experimental aluminum pathology in rabbits: effects of hydrophilic and lipophilic compounds.
por: Bombi, G G, et al.
Publicado: (1990)

Micelles of Oxyethylated Isononylphenols in Aqueous Solutions and Hydrophilic–Lipophilic Balance
por: Arkhipov, Victor P., et al.
Publicado: (2020)

High-Precision Automated Workflow for Urinary Untargeted Metabolomic Epidemiology
por: Meister, Isabel, et al.
Publicado: (2021)

The Effects of Sampling and Storage Conditions on the Metabolite Profile of the Marine Sponge Geodia barretti
por: Erngren, Ida, et al.
Publicado: (2021)

Hydrophilic and lipophilic radiopharmaceuticals as tracers in pharmaceutical development: In vitro – In vivo studies
por: Terán, Mariella, et al.
Publicado: (2005)

SAT-356 Differential Effects of Lipophilic and Hydrophilic Statins on Aldosterone Biosynthesis
por: Maris, Stephen, et al.
Publicado: (2019)

Lipomics: A Potential Carrier for the Intravenous Delivery of Lipophilic and Hydrophilic Drugs
por: Ramírez-Hernández, David, et al.
Publicado: (2022)

Assessment of coverage for endogenous metabolites and exogenous chemical compounds using an untargeted metabolomics platform
por: Kong, Sek Won, et al.
Publicado: (2020)

Comparison of Clinical Outcomes of Hydrophilic and Lipophilic Statins in Patients with Acute Myocardial Infarction
por: Kim, Min Chul, et al.
Publicado: (2011)

Controlled-Release Carbamazepine Matrix Granules and Tablets Comprising Lipophilic and Hydrophilic Components
por: Barakat, Nahla S., et al.
Publicado: (2009)

Interlaboratory Coverage Test on Plant Food Bioactive Compounds and Their Metabolites by Mass Spectrometry-Based Untargeted Metabolomics
por: Koistinen, Ville Mikael, et al.
Publicado: (2018)

Anabolic androgenic steroids exert a selective remodeling of the plasma lipidome that mirrors the decrease of the de novo lipogenesis in the liver
por: Balgoma, David, et al.
Publicado: (2020)

Untargeted UPLC-MS Profiling Pipeline to Expand Tissue Metabolome Coverage: Application to Cardiovascular Disease
por: Vorkas, Panagiotis A., et al.
Publicado: (2015)

Mathematical Modelling of Hydrophilic Ionic Fertiliser Diffusion in Plant Cuticles: Lipophilic Surfactant Effects
por: Tredenick, Eloise C., et al.
Publicado: (2019)

Effects of the Hydrophilic–Lipophilic Balance of Alternating Peptides on Self-Assembly and Thermo-Responsive Behaviors
por: Ihsan, Abu Bin, et al.
Publicado: (2019)

Association of venous thromboembolism between hydrophilic and lipophilic statin users among diabetic subjects
por: Hu, Wei-Syun, et al.
Publicado: (2022)

Efficacy of hydrophilic or lipophilic emulsions containing Echinacea purpurea extract in treatment of different types of pruritus
por: Kilic, Ana, et al.
Publicado: (2018)

Lipid-polymer hybrid nanoparticles for controlled delivery of hydrophilic and lipophilic doxorubicin for breast cancer therapy
por: Tahir, Nayab, et al.
Publicado: (2019)

The Risk of Muscular Events Among New Users of Hydrophilic and Lipophilic Statins: an Observational Cohort Study
por: Mueller, Alexandra M., et al.
Publicado: (2021)

Modulation of solid surface with desirable under-liquid wettability based on molecular hydrophilic–lipophilic balance
por: Wang, Yang, et al.
Publicado: (2021)

Efficacy of Natural Deep Eutectic Solvents for Extraction of Hydrophilic and Lipophilic Compounds from Fucus vesiculosus
por: Obluchinskaya, Ekaterina D., et al.
Publicado: (2021)

Association of venous thromboembolism between hydrophilic and lipophilic statin users among diabetic subjects: Erratum
Publicado: (2022)

Hydrophilic Versus Lipophilic Statin Treatments in Patients With Renal Impairment After Acute Myocardial Infarction
por: Kang, Min Hye, et al.
Publicado: (2022)

Lipophilic and Hydrophilic Compounds from Arthrospira platensis and Its Effects on Tissue and Blood Cells—An Overview
por: Jung, Friedrich, et al.
Publicado: (2022)

Untargeted Metabolomics for Integrative Taxonomy: Metabolomics, DNA Marker-Based Sequencing, and Phenotype Bioimaging
por: Peters, Kristian, et al.
Publicado: (2023)

Combined hydrophilic interaction liquid chromatography-scanning field asymmetric waveform ion mobility spectrometry-time-of-flight mass spectrometry for untargeted metabolomics
por: Szykuła, Katarzyna M., et al.
Publicado: (2019)

New plasma preparation approach to enrich metabolome coverage in untargeted metabolomics: plasma protein bound hydrophobic metabolite release with proteinase K
por: Wawrzyniak, Renata, et al.
Publicado: (2018)

Investigation of Equine In Vivo and In Vitro Derived Metabolites of the Selective Androgen Receptor Modulator (SARM) ACP-105 for Improved Doping Control
por: Broberg, Malin Nilsson, et al.
Publicado: (2021)

Simultaneous determination of hydrophilic and lipophilic constituents in herbal medicines using directly-coupled reversed-phase and hydrophilic interaction liquid chromatography-tandem mass spectrometry
por: Sun, Wan-Yang, et al.
Publicado: (2017)

Untargeted Metabolomic Characterization of Ovarian Tumors
por: Liu, Xiaona, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_k2fupfgolrspdudl4tq87dacvv