Distinction between 2′- and 3′-Phosphate Isomers of a Fluorescent NADPH Analogue Led to Strong Inhibition of Cancer Cells Migration

Specific inhibition of NADPH oxidases (NOX) and NO-synthases (NOS), two enzymes associated with redox stress in tumor cells, has aroused great pharmacological interest. Here, we show how these enzymes distinguish between isomeric 2′- and 3′-phosphate derivatives, a difference used to improve the spe...

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Detalles Bibliográficos
Autores principales: Manuel, Raoul, Lima, Michelle de Souza, Dilly, Sébastien, Daunay, Sylvain, Abbe, Patricia, Pramil, Elodie, Solier, Stéphanie, Guillaumond, Fabienne, Tubiana, Sarah-Simha, Escargueil, Alexandre, Pêgas Henriques, João Antonio, Ferrand, Nathalie, Erdelmeier, Irène, Boucher, Jean-Luc, Bertho, Gildas, Agranat, Israel, Rocchi, Stéphane, Sabbah, Michèle, Slama Schwok, Anny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148004/
https://www.ncbi.nlm.nih.gov/pubmed/34064498
http://dx.doi.org/10.3390/antiox10050723

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148004/
https://www.ncbi.nlm.nih.gov/pubmed/34064498
http://dx.doi.org/10.3390/antiox10050723

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