Tryptophan scanning mutagenesis as a way to mimic the compound-bound state and probe the selectivity of allosteric inhibitors in cells

Understanding the selectivity of a small molecule for its target(s) in cells is an important goal in chemical biology and drug discovery. One powerful way to address this question is with dominant negative (DN) mutants, in which an active site residue in the putative target is mutated. While powerfu...

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Detalles Bibliográficos
Autores principales: Taylor, Isabelle R., Assimon, Victoria A., Kuo, Szu Yu, Rinaldi, Silvia, Li, Xiaokai, Young, Zapporah T., Morra, Giulia, Green, Keith, Nguyen, Daniel, Shao, Hao, Garneau-Tsodikova, Sylvie, Colombo, Giorgio, Gestwicki, Jason E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148087/
https://www.ncbi.nlm.nih.gov/pubmed/34123282
http://dx.doi.org/10.1039/c9sc04284a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148087/
https://www.ncbi.nlm.nih.gov/pubmed/34123282
http://dx.doi.org/10.1039/c9sc04284a

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