Protein Expression Correlates Linearly with mRNA Dose over Up to Five Orders of Magnitude In Vitro and In Vivo

Messenger RNA is rapidly gaining significance as a therapeutic modality. Here, we address the dependence of dose–response functions on the type of delivery vehicle, cell line, and incubation time. Knowledge of these characteristics is crucial for the application of mRNA. As delivery vehicles, a lipi...

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Detalles Bibliográficos
Autores principales: van Asbeck, Alexander H., Dieker, Jürgen, Oude Egberink, Rik, van den Berg, Lennard, van der Vlag, Johan, Brock, Roland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148180/
https://www.ncbi.nlm.nih.gov/pubmed/34063094
http://dx.doi.org/10.3390/biomedicines9050511

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148180/
https://www.ncbi.nlm.nih.gov/pubmed/34063094
http://dx.doi.org/10.3390/biomedicines9050511

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