Cargando…

Generation of mitochondrial reactive oxygen species is controlled by ATPase inhibitory factor 1 and regulates cognition

The mitochondrial ATP synthase emerges as key hub of cellular functions controlling the production of ATP, cellular signaling, and fate. It is regulated by the ATPase inhibitory factor 1 (IF1), which is highly abundant in neurons. Herein, we ablated or overexpressed IF1 in mouse neurons to show that...

Descripción completa

Detalles Bibliográficos
Autores principales:	Esparza-Moltó, Pau B., Romero-Carramiñana, Inés, Núñez de Arenas, Cristina, Pereira, Marta P., Blanco, Noelia, Pardo, Beatriz, Bates, Georgina R., Sánchez-Castillo, Carla, Artuch, Rafael, Murphy, Michael P., Esteban, José A., Cuezva, José M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148373/ https://www.ncbi.nlm.nih.gov/pubmed/33983919 http://dx.doi.org/10.1371/journal.pbio.3001252

Ejemplares similares

The ATPase Inhibitory Factor 1 is a Tissue-Specific Physiological Regulator of the Structure and Function of Mitochondrial ATP Synthase: A Closer Look Into Neuronal Function
por: Domínguez-Zorita, Sonia, et al.
Publicado: (2022)

IF1 promotes oligomeric assemblies of sluggish ATP synthase and outlines the heterogeneity of the mitochondrial membrane potential
por: Romero-Carramiñana, Inés, et al.
Publicado: (2023)

IF1 ablation prevents ATP synthase oligomerization, enhances mitochondrial ATP turnover and promotes an adenosine-mediated pro-inflammatory phenotype
por: Domínguez-Zorita, Sonia, et al.
Publicado: (2023)

The Role of Mitochondrial H(+)-ATP Synthase in Cancer
por: Esparza-Moltó, Pau B., et al.
Publicado: (2018)

Analysis of the metabolic proteome of lung adenocarcinomas by reverse-phase protein arrays (RPPA) emphasizes mitochondria as targets for therapy
por: Torresano, Laura, et al.
Publicado: (2022)

Regulation of the H(+)-ATP synthase by IF1: a role in mitohormesis
por: Esparza-Moltó, Pau B., et al.
Publicado: (2017)

Pyruvate kinase M2 and the mitochondrial ATPase Inhibitory Factor 1 provide novel biomarkers of dermatomyositis: a metabolic link to oncogenesis
por: Santacatterina, Fulvio, et al.
Publicado: (2017)

Overexpression of the ATPase Inhibitory Factor 1 Favors a Non-metastatic Phenotype in Breast Cancer
por: García-Ledo, Lucía, et al.
Publicado: (2017)

Down-regulation of oxidative phosphorylation in the liver by expression of the ATPase inhibitory factor 1 induces a tumor-promoter metabolic state
por: Santacatterina, Fulvio, et al.
Publicado: (2015)

Expression, regulation and clinical relevance of the ATPase inhibitory factor 1 in human cancers
por: Sánchez-Aragó, M, et al.
Publicado: (2013)

The mitochondrial ATP synthase is a shared drug target for aging and dementia
por: Goldberg, Joshua, et al.
Publicado: (2018)

Effective therapeutic strategies in a preclinical mouse model of Charcot–Marie–Tooth disease
por: Nuevo-Tapioles, Cristina, et al.
Publicado: (2021)

Evolution of the Inhibitory and Non-Inhibitory ε, ζ, and IF(1) Subunits of the F(1)F(O)-ATPase as Related to the Endosymbiotic Origin of Mitochondria
por: Mendoza-Hoffmann, Francisco, et al.
Publicado: (2022)

Early Social Isolation Stress and Perinatal NMDA Receptor Antagonist Treatment Induce Changes in the Structure and Neurochemistry of Inhibitory Neurons of the Adult Amygdala and Prefrontal Cortex
por: Castillo-Gómez, Esther, et al.
Publicado: (2017)

Quantitative analysis of proteins of metabolism by reverse phase protein microarrays identifies potential biomarkers of rare neuromuscular diseases
por: Santacatterina, Fulvio, et al.
Publicado: (2015)

Inhibitory to non-inhibitory evolution of the ζ subunit of the F(1)F(O)-ATPase of Paracoccus denitrificans and α-proteobacteria as related to mitochondrial endosymbiosis
por: Mendoza-Hoffmann, Francisco, et al.
Publicado: (2023)

Inhibitory and combinatorial effect of diphyllin, a v-ATPase blocker, on influenza viruses
por: Chen, Hui-Wen, et al.
Publicado: (2013)

Reduction of the ATPase inhibitory factor 1 (IF(1)) leads to visual impairment in vertebrates
por: Martín-Jiménez, Rebeca, et al.
Publicado: (2018)

Role for the ATPase inhibitory factor 1 in the environmental carcinogen-induced Warburg phenotype
por: Hardonnière, Kévin, et al.
Publicado: (2017)

Coordinate β-adrenergic inhibition of mitochondrial activity and angiogenesis arrest tumor growth
por: Nuevo-Tapioles, Cristina, et al.
Publicado: (2020)

In vitro H(+) -K(+) ATPase inhibitory potential of methanolic extract of Cissus quadrangularis Linn.
por: Yadav, Priyanka, et al.
Publicado: (2012)

ATPase inhibitory factor 1 is a potential prognostic marker for the migration and invasion of glioma
por: WU, JIANHENG, et al.
Publicado: (2015)

Thiacalix[4]arenes Remove the Inhibitory Effects of Zn Cations on the Myosin ATPase Activity
por: Labyntsevа, Raisa, et al.
Publicado: (2018)

Neuroprotective effects of ATPase inhibitory factor 1 preventing mitochondrial dysfunction in Parkinson's disease
por: Chung, InHyeok, et al.
Publicado: (2022)

ATPase Inhibitory Factor 1—A Novel Marker of Cellular Fitness and Exercise Capacity?
por: Domin, Remigiusz, et al.
Publicado: (2022)

Chronic inhibition of the mitochondrial ATP synthase in skeletal muscle triggers sarcoplasmic reticulum distress and tubular aggregates
por: Sánchez-González, Cristina, et al.
Publicado: (2022)

The bioenergetic signature of cancer
por: Cuezva, José M
Publicado: (2010)

Brain Na(+), K(+)-ATPase Activity In Aging and Disease
por: de Lores Arnaiz, Georgina Rodríguez, et al.
Publicado: (2014)

Molecular mechanism on forcible ejection of ATPase inhibitory factor 1 from mitochondrial ATP synthase
por: Kobayashi, Ryohei, et al.
Publicado: (2023)

2nd "Guillermo Haro" Conference on Interstellar Turbulence
por: Franco, P, et al.
Publicado: (1998)

Knockout of the ATPase inhibitory factor 1 protects the heart from pressure overload-induced cardiac hypertrophy
por: Yang, Kevin, et al.
Publicado: (2017)

Author Correction: Neuroprotective effects of ATPase inhibitory factor 1 preventing mitochondrial dysfunction in Parkinson's disease
por: Chung, InHyeok, et al.
Publicado: (2022)

Upregulation of mitochondrial ATPase inhibitory factor 1 (ATPIF1) mediates increased glycolysis in mouse hearts
por: Zhou, Bo, et al.
Publicado: (2022)

Mechanism of potassium ion uptake by the Na(+)/K(+)-ATPase
por: Castillo, Juan P., et al.
Publicado: (2015)

Genetic Ablation of Na,K-ATPase α4 Results in Sperm Energetic Defects
por: Numata, September, et al.
Publicado: (2022)

Functional Promiscuity of Homologues of the Bacterial ArsA ATPases
por: Castillo, Rostislav, et al.
Publicado: (2010)

Solar, Stellar and Galactic Connections between Particle Physics and Astrophysics
por: Carraminana, Alberto
Publicado: (2007)

Steroidal and Phenolic Glycosides from the Bulbs of Lilium pumilum DC and Their Potential Na(+)/K(+) ATPase Inhibitory Activity
por: Zhou, Zhong-Liu, et al.
Publicado: (2012)

Kinetic analysis of the inhibition mechanism of bovine mitochondrial F(1)-ATPase inhibitory protein using biochemical assay
por: Kobayashi, Ryohei, et al.
Publicado: (2021)

ATPase Inhibitory Factor 1 Is Critical for Regulating Sevoflurane-Induced Microglial Inflammatory Responses and Caspase-3 Activation
por: Xu, Yaru, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_lov8tcm7m7eeg5n4od0bvudste