The nuclear sirtuin SIRT6 protects the heart from developing aging-associated myocyte senescence and cardiac hypertrophy

Sirtuins have been shown to regulate the aging process. We have previously demonstrated that Sirt6 blocks the pressure overload-induced cardiac hypertrophy in mice. Here, we show that Sirt6 can also mitigate aging-induced cardiomyocyte senescence and cardiac hypertrophy. We found that aging is assoc...

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Detalles Bibliográficos
Autores principales: Pillai, Vinodkumar B., Samant, Sadhana, Hund, Samantha, Gupta, Madhu, Gupta, Mahesh P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148452/
https://www.ncbi.nlm.nih.gov/pubmed/33934090
http://dx.doi.org/10.18632/aging.203027

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148452/
https://www.ncbi.nlm.nih.gov/pubmed/33934090
http://dx.doi.org/10.18632/aging.203027

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