Investigation of Supercharging as A Strategy to Enhance the Solubility and Plasminogen Cleavage Activity of Reteplase

BACKGROUND: Reteplase, the recombinant form of tissue plasminogen activator, is a thrombolytic drug with outstanding characteristics, while demonstrating limited solubility and reduced plasminogen activation. Previously, we in silico designed a variant of Reteplase with positively supercharged surfa...

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Detalles Bibliográficos
Autores principales: Seyedhosseini Ghaheh, Hooria, Ganjalikhany, Mohamad Reza, Yaghmaei, Parichehreh, Pourfarzam, Morteza, Mir Mohammad Sadeghi, Hamid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Institute of Genetic Engineering and Biotechnology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148640/
https://www.ncbi.nlm.nih.gov/pubmed/34056023
http://dx.doi.org/10.30498/IJB.2020.2556

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148640/
https://www.ncbi.nlm.nih.gov/pubmed/34056023
http://dx.doi.org/10.30498/IJB.2020.2556

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