Downregulation of glial genes involved in synaptic function mitigates Huntington's disease pathogenesis

Most research on neurodegenerative diseases has focused on neurons, yet glia help form and maintain the synapses whose loss is so prominent in these conditions. To investigate the contributions of glia to Huntington's disease (HD), we profiled the gene expression alterations of Drosophila expre...

Descripción completa

Detalles Bibliográficos
Autores principales: Onur, Tarik Seref, Laitman, Andrew, Zhao, He, Keyho, Ryan, Kim, Hyemin, Wang, Jennifer, Mair, Megan, Wang, Huilan, Li, Lifang, Perez, Alma, de Haro, Maria, Wan, Ying-Wooi, Allen, Genevera, Lu, Boxun, Al-Ramahi, Ismael, Liu, Zhandong, Botas, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Computational and Systems Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8149125/
https://www.ncbi.nlm.nih.gov/pubmed/33871358
http://dx.doi.org/10.7554/eLife.64564

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8149125/
https://www.ncbi.nlm.nih.gov/pubmed/33871358
http://dx.doi.org/10.7554/eLife.64564

Ejemplares similares