Cargando…

Downregulation of glial genes involved in synaptic function mitigates Huntington's disease pathogenesis

Most research on neurodegenerative diseases has focused on neurons, yet glia help form and maintain the synapses whose loss is so prominent in these conditions. To investigate the contributions of glia to Huntington's disease (HD), we profiled the gene expression alterations of Drosophila expre...

Descripción completa

Detalles Bibliográficos
Autores principales:	Onur, Tarik Seref, Laitman, Andrew, Zhao, He, Keyho, Ryan, Kim, Hyemin, Wang, Jennifer, Mair, Megan, Wang, Huilan, Li, Lifang, Perez, Alma, de Haro, Maria, Wan, Ying-Wooi, Allen, Genevera, Lu, Boxun, Al-Ramahi, Ismael, Liu, Zhandong, Botas, Juan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2021
Materias:	Computational and Systems Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8149125/ https://www.ncbi.nlm.nih.gov/pubmed/33871358 http://dx.doi.org/10.7554/eLife.64564

Ejemplares similares

SPA-STOCSY: An Automated Tool for Identification of Annotated and Non-Annotated Metabolites in High-Throughput NMR Spectra
por: Han, Xu, et al.
Publicado: (2023)

SPA-STOCSY: an automated tool for identifying annotated and non-annotated metabolites in high-throughput NMR spectra
por: Han, Xu, et al.
Publicado: (2023)

An altered extracellular matrix–integrin interface contributes to Huntington’s disease-associated CNS dysfunction in glial and vascular cells
por: Hernandez, Sarah J, et al.
Publicado: (2022)

On the Reproducibility of TCGA Ovarian Cancer MicroRNA Profiles
por: Wan, Ying-Wooi, et al.
Publicado: (2014)

Molecular pathway identification using biological network-regularized logistic models
por: Zhang, Wen, et al.
Publicado: (2013)

XMRF: an R package to fit Markov Networks to high-throughput genetics data
por: Wan, Ying-Wooi, et al.
Publicado: (2016)

A Genome-Scale RNA–Interference Screen Identifies RRAS Signaling as a Pathologic Feature of Huntington's Disease
por: Miller, John P., et al.
Publicado: (2012)

Smaug/SAMD4A Restores Translational Activity of CUGBP1 and Suppresses CUG-Induced Myopathy
por: de Haro, Maria, et al.
Publicado: (2013)

dAtaxin-2 Mediates Expanded Ataxin-1-Induced Neurodegeneration in a Drosophila Model of SCA1
por: Al-Ramahi, Ismael, et al.
Publicado: (2007)

Hunting out the repeat expansion in Huntington’s pigs
por: Yang, Guang, et al.
Publicado: (2023)

Glial Cells and Synaptic Plasticity
por: Wang, Fushun, et al.
Publicado: (2016)

A striatal-enriched intronic GPCR modulates huntingtin levels and toxicity
por: Yao, Yuwei, et al.
Publicado: (2015)

Corticostriatal synaptic adaptations in Huntington’s disease
por: Plotkin, Joshua L., et al.
Publicado: (2015)

Circuit Stability to Perturbations Reveals Hidden Variability in the Balance of Intrinsic and Synaptic Conductances
por: Onasch, Sebastian, et al.
Publicado: (2020)

Tau polarizes an aging transcriptional signature to excitatory neurons and glia
por: Wu, Timothy, et al.
Publicado: (2023)

In vitro characterization of intrinsic properties and local synaptic inputs to pyramidal neurons in macaque primary motor cortex
por: Xu, Wei, et al.
Publicado: (2018)

Alteration of Autophagy and Glial Activity in Nilotinib-Treated Huntington’s Disease Patients
por: Anderson, Karen E., et al.
Publicado: (2022)

Synaptic deficits in sepsis: role of glial cells
por: Moraes, Carolina A, et al.
Publicado: (2013)

Depression as a Glial-Based Synaptic Dysfunction
por: Rial, Daniel, et al.
Publicado: (2016)

Glial cells in anorexia
por: Reyes-Haro, Daniel
Publicado: (2022)

Synaptic pathology in Huntington’s disease: Beyond the corticostriatal pathway
por: Barry, Joshua, et al.
Publicado: (2022)

A unified computational model for cortical post-synaptic plasticity
por: Mäki-Marttunen, Tuomo, et al.
Publicado: (2020)

Optimal plasticity for memory maintenance during ongoing synaptic change
por: Raman, Dhruva V, et al.
Publicado: (2021)

Functional screening of lysosomal storage disorder genes identifies modifiers of alpha-synuclein neurotoxicity
por: Yu, Meigen, et al.
Publicado: (2023)

Neural oscillations as a signature of efficient coding in the presence of synaptic delays
por: Chalk, Matthew, et al.
Publicado: (2016)

EEG alpha and pupil diameter reflect endogenous auditory attention switching and listening effort
por: Haro, Stephanie, et al.
Publicado: (2022)

The principal neurons of the medial nucleus of the trapezoid body and NG2(+) glial cells receive coordinated excitatory synaptic input
por: Müller, Jochen, et al.
Publicado: (2009)

Evaluation of Blood Glial Fibrillary Acidic Protein as a Potential Marker in Huntington's Disease
por: You, Huajing, et al.
Publicado: (2021)

The glial growth factors deficiency and synaptic destabilization hypothesis of schizophrenia
por: Moises, Hans W, et al.
Publicado: (2002)

Comprehensive evaluation of RNA-seq quantification methods for linearity
por: Jin, Haijing, et al.
Publicado: (2017)

Inhibition enhances spatially-specific calcium encoding of synaptic input patterns in a biologically constrained model
por: Dorman, Daniel B, et al.
Publicado: (2018)

Synaptic RTP801 contributes to motor-learning dysfunction in Huntington’s disease
por: Martín-Flores, Núria, et al.
Publicado: (2020)

Do Changes in Synaptic Autophagy Underlie the Cognitive Impairments in Huntington’s Disease?
por: Grosso Jasutkar, Hilary, et al.
Publicado: (2021)

Glial Processes at the Drosophila Larval Neuromuscular Junction Match Synaptic Growth
por: Brink, Deidre L., et al.
Publicado: (2012)

Regulatory effects of inhibiting the activation of glial cells on retinal synaptic plasticity
por: Zhou, Lihong, et al.
Publicado: (2014)

Glial-neuronal ensembles: partners in drug addiction-associated synaptic plasticity
por: Cadet, Jean Lud, et al.
Publicado: (2014)

The International Conference on Intelligent Biology and Medicine (ICIBM) 2016: from big data to big analytical tools
por: Liu, Zhandong, et al.
Publicado: (2017)

Synaptic Cell Adhesion Molecule 3 (SynCAM3) Deletion Promotes Recovery from Spinal Cord Injury by Limiting Glial Scar Formation
por: Song, Byeong Gwan, et al.
Publicado: (2022)

Inferring signaling pathways with probabilistic programming
por: Merrell, David, et al.
Publicado: (2020)

FBA reveals guanylate kinase as a potential target for antiviral therapies against SARS-CoV-2
por: Renz, Alina, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_mn3russ87ceuou8rr361bmckh0