Rescue of retinal ganglion cells in optic nerve injury using cell-selective AAV mediated delivery of SIRT1

SIRT1 prevents retinal ganglion cell (RGC) loss in models of optic neuropathy following pharmacologic activation or genetic overexpression. The exact mechanism of loss is not known, prior evidence suggests this is through oxidative stress to either neighboring cells or RGC specifically. We investiga...

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Detalles Bibliográficos
Autores principales: Ross, Ahmara G., McDougald, Devin S., Khan, Reas S., Duong, Thu T., Dine, Kimberly E., Aravand, Puya, Bennett, Jean, Chavali, Venkata Ramana Murthy, Shindler, Kenneth S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8149296/
https://www.ncbi.nlm.nih.gov/pubmed/33589779
http://dx.doi.org/10.1038/s41434-021-00219-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8149296/
https://www.ncbi.nlm.nih.gov/pubmed/33589779
http://dx.doi.org/10.1038/s41434-021-00219-z

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