Rescue of retinal ganglion cells in optic nerve injury using cell-selective AAV mediated delivery of SIRT1
SIRT1 prevents retinal ganglion cell (RGC) loss in models of optic neuropathy following pharmacologic activation or genetic overexpression. The exact mechanism of loss is not known, prior evidence suggests this is through oxidative stress to either neighboring cells or RGC specifically. We investiga...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8149296/ https://www.ncbi.nlm.nih.gov/pubmed/33589779 http://dx.doi.org/10.1038/s41434-021-00219-z |