Integrative metabolomics and transcriptomics identifies itaconate as an adjunct therapy to treat ocular bacterial infection

The eye is highly susceptible to inflammation-mediated tissue damage evoked during bacterial infection. However, mechanisms regulating inflammation to protect the eye remain elusive. Here, we used integrated metabolomics and transcriptomics to show that the immunomodulatory metabolite itaconate and...

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Detalles Bibliográficos
Autores principales: Singh, Sukhvinder, Singh, Pawan Kumar, Jha, Alokkumar, Naik, Poonam, Joseph, Joveeta, Giri, Shailendra, Kumar, Ashok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8149370/
https://www.ncbi.nlm.nih.gov/pubmed/34095879
http://dx.doi.org/10.1016/j.xcrm.2021.100277

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8149370/
https://www.ncbi.nlm.nih.gov/pubmed/34095879
http://dx.doi.org/10.1016/j.xcrm.2021.100277

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