Cargando…

Efficacy, safety and tolerability of drugs studied in phase 3 randomized controlled trials in solid tumors over the last decade

Data suggest that for newly approved cancer drugs safety and tolerability are worse than in control arms of registration trials. Less is known about the balance between efficacy and toxicity of drugs studied in unselected phase 3 randomized controlled trials (RCTs) including those not resulting in r...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ribnikar, Domen, Goldvaser, Hadar, Veitch, Zachary W., Ocana, Alberto, Templeton, Arnoud J., Šeruga, Boštjan, Amir, Eitan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8149406/ https://www.ncbi.nlm.nih.gov/pubmed/34035370 http://dx.doi.org/10.1038/s41598-021-90403-3

Ejemplares similares

Associations between safety, tolerability, and toxicity and the reporting of health‐related quality of life in phase III randomized trials in common solid tumors
por: Saleh, Ramy R., et al.
Publicado: (2020)

Association between PIK3CA activating mutations and outcomes in early-stage invasive lobular breast carcinoma treated with adjuvant systemic therapy
por: Ribnikar, Domen, et al.
Publicado: (2023)

Deescalating Adjuvant Trastuzumab in HER2-Positive Early-Stage Breast Cancer: A Systemic Review and Meta-Analysis
por: Goldvaser, Hadar, et al.
Publicado: (2019)

Clinical benefit of cancer drugs approved in Switzerland 2010–2019
por: Adam, Roman, et al.
Publicado: (2022)

Extended Adjuvant Tamoxifen for Early Breast Cancer: A Meta-Analysis
por: Al-Mubarak, Mustafa, et al.
Publicado: (2014)

Role of cooperative groups and funding source in clinical trials supporting guidelines for systemic therapy of breast cancer
por: Tibau, Ariadna, et al.
Publicado: (2018)

Activation of the PI3K/mTOR/AKT Pathway and Survival in Solid Tumors: Systematic Review and Meta-Analysis
por: Ocana, Alberto, et al.
Publicado: (2014)

Cardiovascular Toxicity of Multi-Tyrosine Kinase Inhibitors in Advanced Solid Tumors: A Population-Based Observational Study
por: Srikanthan, Amirrtha, et al.
Publicado: (2015)

Impact of comorbidity on the outcome in men with advanced prostate cancer treated with docetaxel
por: Zist, Andrej, et al.
Publicado: (2015)

In silico analyses identify gene-sets, associated with clinical outcome in ovarian cancer: role of mitotic kinases
por: Ocaña, Alberto, et al.
Publicado: (2016)

Interaction between Hormonal Receptor Status, Age and Survival in Patients with BRCA1/2 Germline Mutations: A Systematic Review and Meta-Regression
por: Templeton, Arnoud J., et al.
Publicado: (2016)

Influence of companion diagnostics on efficacy and safety of targeted anti-cancer drugs: systematic review and meta-analyses
por: Ocana, Alberto, et al.
Publicado: (2015)

Outcome for Children with Metastatic Solid Tumors over the Last Four Decades
por: Perkins, Stephanie M., et al.
Publicado: (2014)

Response to Soran et al.
por: Reinhorn, Daniel, et al.
Publicado: (2021)

Considerations for the clinical development of immuno-oncology agents in cancer
por: Pandiella, Atanasio, et al.
Publicado: (2023)

The Prognostic Value of Neutrophil-to-Lymphocyte Ratio in Metastatic Testicular Cancer
por: Ribnikar, Domen, et al.
Publicado: (2020)

Efficacy and Safety of the Addition of Internal Mammary Irradiation to Standard Adjuvant Radiation in Early-Stage Breast Cancer: A Systematic Review and Meta-Analysis
por: Korzets, Yasmin, et al.
Publicado: (2022)

Invertebrate Iridoviruses: A Glance over the Last Decade
por: İnce, İkbal Agah, et al.
Publicado: (2018)

Progress of orthopaedic research in China over the last decade
por: Lin, Jun, et al.
Publicado: (2020)

Injectable Hydrogels for Cancer Therapy over the Last Decade
por: Cirillo, Giuseppe, et al.
Publicado: (2019)

Women in academic surgery over the last four decades
por: Linscheid, Laura J., et al.
Publicado: (2020)

Progress in Soybean Genetic Transformation Over the Last Decade
por: Xu, Hu, et al.
Publicado: (2022)

Association of Obesity With Breast Cancer Outcome in Relation to Cancer Subtypes: A Meta-Analysis
por: Lohmann, Ana Elisa, et al.
Publicado: (2021)

Much has changed in the last decade except overall survival: A Swiss single center analysis of treatment and survival in patients with stage IV non-small cell lung cancer
por: Wallrabenstein, Till, et al.
Publicado: (2020)

Locoregional therapy in de novo metastatic breast cancer: Systemic review and meta-analysis
por: Reinhorn, Daniel, et al.
Publicado: (2021)

Treatment of Laryngoceles: What Is the Progress over the Last Two Decades?
por: Zelenik, Karol, et al.
Publicado: (2014)

Advances in Type 1 Diabetes Technology Over the Last Decade
por: Zimmerman, Chelsea, et al.
Publicado: (2019)

Biologic therapy for Crohn’s disease over the last 3 decades
por: Shen, Ji-Liang, et al.
Publicado: (2022)

FDA-Approved Pharmacotherapy for Weight Loss Over the Last Decade
por: Idrees, Zarwa, et al.
Publicado: (2022)

Authorship Trends of Emergency Medicine Publications over the Last Two Decades
por: Lammers, Richard, et al.
Publicado: (2016)

Oral Clefting in China Over the Last Decade: 205,679 Patients
por: Kling, Rochelle R., et al.
Publicado: (2014)

Characteristics and Trends of Published Adult Hip Research over the Last Decade
por: Kwak, Hong Suk, et al.
Publicado: (2015)

Prostate cancer in East Asia: evolving trend over the last decade
por: Zhu, Yao, et al.
Publicado: (2015)

Multidimensional Poverty in Indonesia: Trend Over the Last Decade (2003–2013)
por: Hanandita, Wulung, et al.
Publicado: (2015)

Pain relief after ambulatory surgery: Progress over the last decade
por: Jafra, Anudeep, et al.
Publicado: (2018)

Artificial liver support systems: what is new over the last decade?
por: García Martínez, Juan José, et al.
Publicado: (2018)

Successes and challenges of the One Health approach in Kenya over the last decade
por: Munyua, Peninah M., et al.
Publicado: (2019)

Urban population exposure to air pollution in Europe over the last decades
por: Sicard, Pierre, et al.
Publicado: (2021)

Starch biosynthesis in cereal endosperms: An updated review over the last decade
por: Huang, Lichun, et al.
Publicado: (2021)

Intrapartum Analgesia—Have Women’s Preferences Changed over the Last Decade?
por: Jodzis, Agnieszka, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_f0c6j5hslep78jskkbev63ckkf