NOTCH3-targeted antibody drug conjugates regress tumors by inducing apoptosis in receptor cells and through transendocytosis into ligand cells

Aberrant NOTCH3 signaling and overexpression is oncogenic, associated with cancer stem cells and drug resistance, yet therapeutic targeting remains elusive. Here, we develop NOTCH3-targeted antibody drug conjugates (NOTCH3-ADCs) by bioconjugation of an auristatin microtubule inhibitor through a prot...

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Detalles Bibliográficos
Autores principales: Geles, Kenneth G., Gao, Yijie, Giannakou, Andreas, Sridharan, Latha, Yamin, Ting-Ting, Zhang, Jing, Karim, Riyez, Bard, Joel, Piche-Nicholas, Nicole, Charati, Manoj, Maderna, Andreas, Lucas, Judy, Golas, Jonathon, Guffroy, Magali, Pirie-Shepherd, Steven, Roy, Marc, Qian, Jessie, Franks, Tania, Zhong, Wenyan, O’Donnell, Christopher J., Tchistiakova, Lioudmila, Gerber, Hans-Peter, Sapra, Puja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8149476/
https://www.ncbi.nlm.nih.gov/pubmed/34095881
http://dx.doi.org/10.1016/j.xcrm.2021.100279

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8149476/
https://www.ncbi.nlm.nih.gov/pubmed/34095881
http://dx.doi.org/10.1016/j.xcrm.2021.100279

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