Small-molecule inhibition of Lats kinases may promote Yap-dependent proliferation in postmitotic mammalian tissues

Hippo signaling is an evolutionarily conserved pathway that restricts growth and regeneration predominantly by suppressing the activity of the transcriptional coactivator Yap. Using a high-throughput phenotypic screen, we identified a potent and non-toxic activator of Yap. In vitro kinase assays sho...

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Detalles Bibliográficos
Autores principales: Kastan, Nathaniel, Gnedeva, Ksenia, Alisch, Theresa, Petelski, Aleksandra A., Huggins, David J., Chiaravalli, Jeanne, Aharanov, Alla, Shakked, Avraham, Tzahor, Eldad, Nagiel, Aaron, Segil, Neil, Hudspeth, A. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8149661/
https://www.ncbi.nlm.nih.gov/pubmed/34035288
http://dx.doi.org/10.1038/s41467-021-23395-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8149661/
https://www.ncbi.nlm.nih.gov/pubmed/34035288
http://dx.doi.org/10.1038/s41467-021-23395-3

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