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Activation of Prp28 ATPase by phosphorylated Npl3 at a critical step of spliceosome remodeling
Splicing, a key step in the eukaryotic gene-expression pathway, converts precursor messenger RNA (pre-mRNA) into mRNA by excising introns and ligating exons. This task is accomplished by the spliceosome, a macromolecular machine that must undergo sequential conformational changes to establish its ac...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8149812/ https://www.ncbi.nlm.nih.gov/pubmed/34035302 http://dx.doi.org/10.1038/s41467-021-23459-4 |