Cargando…

CBX7 suppresses urinary bladder cancer progression via modulating AKR1B10–ERK signaling

The chromobox (CBX) proteins mediate epigenetic gene silencing and have been implicated in the cancer development. By analyzing eight CBX family members in TCGA dataset, we found that chromobox 7 (CBX7) was the most strikingly downregulated CBX family member in urinary bladder cancer (UBC), as compa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Zhengnan, Yan, Yilin, Zhu, Zhen, Liu, Jiakuan, He, Xiao, Dalangood, Sumiya, Li, Meiqian, Tan, Mingyue, Cai, Jinming, Tang, Pengfei, Huang, Ruimin, Shen, Bing, Yan, Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8149849/ https://www.ncbi.nlm.nih.gov/pubmed/34035231 http://dx.doi.org/10.1038/s41419-021-03819-0

Ejemplares similares

PDE4B Induces Epithelial-to-Mesenchymal Transition in Bladder Cancer Cells and Is Transcriptionally Suppressed by CBX7
por: Huang, Zhengnan, et al.
Publicado: (2021)

Identification of glycogene-type and validation of ST3GAL6 as a biomarker predicts clinical outcome and cancer cell invasion in urinary bladder cancer
por: Dalangood, Sumiya, et al.
Publicado: (2020)

Identification of a novel immune microenvironment signature predicting survival and therapeutic options for bladder cancer
por: Yan, Yilin, et al.
Publicado: (2020)

TEAD4 as a Prognostic Marker Promotes Cell Migration and Invasion of Urinary Bladder Cancer via EMT
por: Huang, Zhengnan, et al.
Publicado: (2021)

Establishment of an optimized orthotopic bladder cancer model in mice
por: Cai, Jinming, et al.
Publicado: (2022)

A novel cuproptosis-related lncRNA signature predicts prognosis and therapeutic response in bladder cancer
por: Cai, Jinming, et al.
Publicado: (2023)

A Novel Ferroptosis-Related Prognostic Signature Reveals Macrophage Infiltration and EMT Status in Bladder Cancer
por: Yan, Yilin, et al.
Publicado: (2021)

Identification of the Prognostic Biomarkers CBX6 and CBX7 in Bladder Cancer
por: Li, Xinxin, et al.
Publicado: (2023)

Pyroptosis-Related Patterns Predict Tumor Immune Landscape and Immunotherapy Response in Bladder Cancer
por: Yan, Yilin, et al.
Publicado: (2022)

A prognostic model based on necroptosis-related genes for prognosis and therapy in bladder cancer
por: Wang, Zeyi, et al.
Publicado: (2023)

AKR1B10 promotes breast cancer cell migration and invasion via activation of ERK signaling
por: Li, Jia, et al.
Publicado: (2017)

Identification of ENO1 as a prognostic biomarker and molecular target among ENOs in bladder cancer
por: Huang, Zhengnan, et al.
Publicado: (2022)

Pao Pereira extract suppresses benign prostatic hyperplasia by inhibiting inflammation-associated NFκB signaling
por: Dong, Yu, et al.
Publicado: (2020)

Rauwolfia vomitoria extract suppresses benign prostatic hyperplasia by inducing autophagic apoptosis through endoplasmic reticulum stress
por: Huang, Guifang, et al.
Publicado: (2022)

Identification of hexosamine biosynthesis pathway as a novel prognostic signature and its correlation with immune infiltration in bladder cancer
por: Cui, Yangyan, et al.
Publicado: (2022)

AKR1B10 in gastrointestinal diseases
por: Shen, Yi, et al.
Publicado: (2015)

Expression of the Aldo-Ketoreductases AKR1B1 and AKR1B10 in Human Cancers
por: Laffin, Brian, et al.
Publicado: (2012)

AKR1B1 and AKR1B10 as Prognostic Biomarkers of Endometrioid Endometrial Carcinomas
por: Hojnik, Marko, et al.
Publicado: (2021)

Diagnostic and prognostic values of AKR1C3 and AKR1D1 in hepatocellular carcinoma
por: Zhu, Pengfei, et al.
Publicado: (2021)

The Role of AKR1B10 in Physiology and Pathophysiology
por: Endo, Satoshi, et al.
Publicado: (2021)

Identification of ST3GAL5 as a prognostic biomarker correlating with CD8(+) T cell exhaustion in clear cell renal cell carcinoma
por: Liu, Jiakuan, et al.
Publicado: (2022)

Single Nucleotide Polymorphisms of CBX4 and CBX7 Decrease the Risk of Hepatocellular Carcinoma
por: Tan, Chao, et al.
Publicado: (2019)

In-silico Investigations of quinine and quinidine as potential Inhibitors of AKR1B1 and AKR1B10: Functional and structural characterization
por: Ejaz, Syeda Abida, et al.
Publicado: (2022)

Up-Regulation of miR-9 Target CBX7 to Regulate Invasion Ability of Bladder Transitional Cell Carcinoma
por: Xie, Dalong, et al.
Publicado: (2015)

Erratum: Upregulation of miR-9 Target CBX7 Regulates Invasion Ability of Bladder Transitional Cell Carcinoma
por: Xie, Dalong, et al.
Publicado: (2020)

Mechanisms of Xiaozheng decoction for anti-bladder cancer effects via affecting the GSK3β/β-catenin signaling pathways: a network pharmacology-directed experimental investigation
por: Zhuang, Jingming, et al.
Publicado: (2023)

Pao Pereira Extract Attenuates Testosterone-Induced Benign Prostatic Hyperplasia in Rats by inhibiting 5α-Reductase
por: Liu, Jiakuan, et al.
Publicado: (2019)

Enzymes of the AKR1B and AKR1C Subfamilies and Uterine Diseases
por: Rižner, Tea Lanišnik
Publicado: (2012)

Structure–Activity Relationships of Cbx7 Inhibitors, Including Selectivity Studies against Other Cbx Proteins
por: Simhadri, Chakravarthi, et al.
Publicado: (2016)

Genome-Wide Screening Identifies Gene AKR1C1 Critical for Resistance to Pirarubicin in Bladder Cancer
por: Nie, Zhenyu, et al.
Publicado: (2023)

LncRNA 1700020I14Rik promotes AKR1B10 expression and activates Erk pathway to induce hepatocyte damage in alcoholic hepatitis
por: Wu, Yue, et al.
Publicado: (2022)

Multiomics integrative analysis reveals antagonistic roles of CBX2 and CBX7 in metabolic reprogramming of breast cancer
por: Iqbal, Mohammad Askandar, et al.
Publicado: (2021)

Genetic variants in AKR1B10 associate with human eating behavior
por: Rohde, Kerstin, et al.
Publicado: (2015)

Prognostic significance of AKR1B10 in patients with resected lung adenocarcinoma
por: Hung, Jung‐Jyh, et al.
Publicado: (2018)

Diagnostic and Prognostic Potential of AKR1B10 in Human Hepatocellular Carcinoma
por: DiStefano, Johanna K., et al.
Publicado: (2019)

The expression and significance of AKR1B10 in laryngeal squamous cell carcinoma
por: Liu, Jixuan, et al.
Publicado: (2021)

CBX3 regulates efficient RNA processing genome-wide
por: Smallwood, Andrea, et al.
Publicado: (2012)

Cbx7 promotes the generation of induced pluripotent stem cells
por: Wang, Chie-Hong, et al.
Publicado: (2023)

CBX3 predicts an unfavorable prognosis and promotes tumorigenesis in osteosarcoma
por: Ma, Chao, et al.
Publicado: (2019)

Expression and prognostic significance of CBX2 in colorectal cancer: database mining for CBX family members in malignancies and vitro analyses
por: Zhou, He, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_bc324kdet4jhffriri8g6n9gjc