Strategies for Targeting Retroviral Integration for Safer Gene Therapy: Advances and Challenges

Retroviruses are obligate intracellular parasites that must integrate a copy of the viral genome into the host DNA. The integration reaction is performed by the viral enzyme integrase in complex with the two ends of the viral cDNA genome and yields an integrated provirus. Retroviral vector particles...

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Detalles Bibliográficos
Autores principales: Yoder, Kristine E., Rabe, Anthony J., Fishel, Richard, Larue, Ross C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8149907/
https://www.ncbi.nlm.nih.gov/pubmed/34055882
http://dx.doi.org/10.3389/fmolb.2021.662331

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8149907/
https://www.ncbi.nlm.nih.gov/pubmed/34055882
http://dx.doi.org/10.3389/fmolb.2021.662331

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