Cargando…

Strategies for Targeting Retroviral Integration for Safer Gene Therapy: Advances and Challenges

Retroviruses are obligate intracellular parasites that must integrate a copy of the viral genome into the host DNA. The integration reaction is performed by the viral enzyme integrase in complex with the two ends of the viral cDNA genome and yields an integrated provirus. Retroviral vector particles...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yoder, Kristine E., Rabe, Anthony J., Fishel, Richard, Larue, Ross C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8149907/ https://www.ncbi.nlm.nih.gov/pubmed/34055882 http://dx.doi.org/10.3389/fmolb.2021.662331

Ejemplares similares

DNA strand breaks and gaps target retroviral intasome binding and integration
por: Senavirathne, Gayan, et al.
Publicado: (2023)

Prototype Foamy Virus Integrase Displays Unique Biochemical Activities among Retroviral Integrases
por: Rabe, Anthony J., et al.
Publicado: (2021)

Retroviral prototype foamy virus intasome binding to a nucleosome target does not determine integration efficiency
por: Kotlar, Randi M., et al.
Publicado: (2021)

CNS-Targeting Therapies for Lysosomal Storage Diseases: Current Advances and Challenges
por: Edelmann, Mariola J., et al.
Publicado: (2020)

Retroviral intasomes search for a target DNA by 1D diffusion which rarely results in integration
por: Jones, Nathan D., et al.
Publicado: (2016)

Editorial: Advances and challenges in untargeted metabolomics
por: Wawrzyniak, Renata, et al.
Publicado: (2023)

A Systematic Strategy to Find Potential Therapeutic Targets for Pseudomonas aeruginosa Using Integrated Computational Models
por: Medeiros Filho, Fernando, et al.
Publicado: (2021)

Challenges of Integrative Disease Modeling in Alzheimer's Disease
por: Golriz Khatami, Sepehr, et al.
Publicado: (2020)

Alternating exosomes and their mimetics as an emergent strategy for targeted cancer therapy
por: Mishra, Lokesh Chandra, et al.
Publicado: (2022)

Recent advances in ferroptosis and therapeutic strategies for glioblastoma
por: Lu, Qixiong, et al.
Publicado: (2023)

Research advances and challenges in tissue-derived extracellular vesicles
por: Zhi, Zhengke, et al.
Publicado: (2022)

Editorial: Gynecological and gastrointestinal cancers: Recent advances in molecular diagnosis and targeted therapy
por: Zhang, Lan, et al.
Publicado: (2023)

Editorial: AI and Multi-Omics for Rare Diseases: Challenges, Advances and Perspectives
por: Bottini, Silvia, et al.
Publicado: (2021)

Multi-Omics Approaches to Improve Mitochondrial Disease Diagnosis: Challenges, Advances, and Perspectives
por: Labory, Justine, et al.
Publicado: (2020)

Advances and challenges in CRISPR-based real-time imaging of dynamic genome organization
por: Thuma, Jenna, et al.
Publicado: (2023)

Molecular Strategies to Target Protein Aggregation in Huntington’s Disease
por: Jarosińska, Olga D., et al.
Publicado: (2021)

Editorial: AI and multi-omics for rare diseases: Challenges, advances and perspectives, Volume II
por: Bottini, Silvia, et al.
Publicado: (2022)

Editorial: Targeting glioblastoma: Mechanisms of pathology and novel therapeutic strategies
por: Kusaczuk, Magdalena, et al.
Publicado: (2023)

Longitudinal omics modeling and integration in clinical metabonomics research: challenges in childhood metabolic health research
por: Sperisen, Peter, et al.
Publicado: (2015)

Recent advances in the understanding of cilia mechanisms and their applications as therapeutic targets
por: Saito, Masaki, et al.
Publicado: (2023)

A strategy for the treatment of gastrointestinal cancer: Targeting tumor senescent cells
por: Liu, Yujing, et al.
Publicado: (2023)

Ligand-Bound Forced Degradation as a Strategy to Generate Functionally Relevant Analytical Challenge Materials for Assessment of CQAs
por: Giddens, John P., et al.
Publicado: (2022)

Editorial: Advances in the therapeutic targeting of human matrix metalloproteinases in health and disease
por: Bharadwaj, Shiv, et al.
Publicado: (2023)

The Role of Notch3 Signaling in Cancer Stemness and Chemoresistance: Molecular Mechanisms and Targeting Strategies
por: Xiu, Mengxi, et al.
Publicado: (2021)

Integrated Strategies of Diverse Feature Selection Methods Identify Aging-Based Reliable Gene Signatures for Ischemic Cardiomyopathy
por: Song, Huafeng, et al.
Publicado: (2022)

Autoimmune Pemphigus: Latest Advances and Emerging Therapies
por: Lim, Yen Loo, et al.
Publicado: (2022)

Editorial: Recent Advances in In Vitro and In Vivo Multi-Omics Analyses of Extracellular Vesicles: Therapeutic Targets and Biomarkers
por: Manfredi, Marcello, et al.
Publicado: (2021)

Molecular mechanisms of retroviral integration site selection
por: Kvaratskhelia, Mamuka, et al.
Publicado: (2014)

Editorial: Advanced nanotechnology for reactive oxygen species-mediated therapies
por: Park, Chun Gwon, et al.
Publicado: (2022)

Integrative Analysis of MALT1 as a Potential Therapeutic Target for Prostate Cancer and its Immunological Role in Pan-Cancer
por: Tan, Haotian, et al.
Publicado: (2021)

Advances and Insights of APC-Asef Inhibitors for Metastatic Colorectal Cancer Therapy
por: Yang, Xiuyan, et al.
Publicado: (2021)

Corrigendum: Editorial: Advanced nanotechnology for reactive oxygen species‐mediated therapies
por: Park, Chun Gwon, et al.
Publicado: (2022)

Editorial: Antiviral drug discovery against pathogens of pandemic concern: Advancements in target site identification and structure-based drug development
por: Padmanabha Das, Krishna M.
Publicado: (2023)

The progress of microenvironment-targeted therapies in brain metastases
por: Long, Lifu, et al.
Publicado: (2023)

Probing the Structural Dynamics of the Plasmodium falciparum Tunneling-Fold Enzyme 6-Pyruvoyl Tetrahydropterin Synthase to Reveal Allosteric Drug Targeting Sites
por: Khairallah, Afrah, et al.
Publicado: (2020)

The Grand Challenge of Characterizing Ribonucleoprotein Networks
por: Tartaglia, Gian Gaetano
Publicado: (2016)

Challenges in predicting stabilizing variations: An exploration
por: Benevenuta, Silvia, et al.
Publicado: (2023)

Development of Nanomaterials to Target Articular Cartilage for Osteoarthritis Therapy
por: Rao, Chenyu, et al.
Publicado: (2022)

The potential of PARP inhibitors in targeted cancer therapy and immunotherapy
por: Hunia, Jaromir, et al.
Publicado: (2022)

Psoriasis immunometabolism: progress on metabolic biomarkers and targeted therapy
por: Sarandi, Evangelia, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_0to8fngeas981ccal6jat6phlb