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ECMarker: interpretable machine learning model identifies gene expression biomarkers predicting clinical outcomes and reveals molecular mechanisms of human disease in early stages

MOTIVATION: Gene expression and regulation, a key molecular mechanism driving human disease development, remains elusive, especially at early stages. Integrating the increasing amount of population-level genomic data and understanding gene regulatory mechanisms in disease development are still chall...

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Detalles Bibliográficos
Autores principales: Jin, Ting, Nguyen, Nam D, Talos, Flaminia, Wang, Daifeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8150141/
https://www.ncbi.nlm.nih.gov/pubmed/33305308
http://dx.doi.org/10.1093/bioinformatics/btaa935