Stability Enhancement of a Dimeric HER2-Specific Affibody Molecule through Sortase A-Catalyzed Head-to-Tail Cyclization

Natural backbone-cyclized proteins have an increased thermostability and resistance towards proteases, characteristics that have sparked interest in head-to-tail cyclization as a method to stability-enhance proteins used in diagnostics and therapeutic applications, for example. In this proof-of prin...

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Detalles Bibliográficos
Autores principales: Westerlund, Kristina, Myrhammar, Anders, Tano, Hanna, Gestin, Maxime, Karlström, Amelie Eriksson
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8150554/
https://www.ncbi.nlm.nih.gov/pubmed/34066245
http://dx.doi.org/10.3390/molecules26102874

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8150554/
https://www.ncbi.nlm.nih.gov/pubmed/34066245
http://dx.doi.org/10.3390/molecules26102874

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