The broad amine scope of pantothenate synthetase enables the synthesis of pharmaceutically relevant amides

Pantothenate synthetase from Escherichia coli (PS(E. coli)) catalyzes the ATP-dependent condensation of (R)-pantoic acid and β-alanine to yield (R)-pantothenic acid (vitamin B(5)), the biosynthetic precursor to coenzyme A. Herein we show that besides the natural amine substrate β-alanine, the enzyme...

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Detalles Bibliográficos
Autores principales: Abidin, Mohammad Z., Saravanan, Thangavelu, Strauss, Erick, Poelarends, Gerrit J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8150671/
https://www.ncbi.nlm.nih.gov/pubmed/33913984
http://dx.doi.org/10.1039/d1ob00238d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8150671/
https://www.ncbi.nlm.nih.gov/pubmed/33913984
http://dx.doi.org/10.1039/d1ob00238d

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