Cargando…

The broad amine scope of pantothenate synthetase enables the synthesis of pharmaceutically relevant amides

Pantothenate synthetase from Escherichia coli (PS(E. coli)) catalyzes the ATP-dependent condensation of (R)-pantoic acid and β-alanine to yield (R)-pantothenic acid (vitamin B(5)), the biosynthetic precursor to coenzyme A. Herein we show that besides the natural amine substrate β-alanine, the enzyme...

Descripción completa

Detalles Bibliográficos
Autores principales:	Abidin, Mohammad Z., Saravanan, Thangavelu, Strauss, Erick, Poelarends, Gerrit J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2021
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8150671/ https://www.ncbi.nlm.nih.gov/pubmed/33913984 http://dx.doi.org/10.1039/d1ob00238d

Ejemplares similares

Modular Enzymatic Cascade Synthesis of Vitamin B(5) and Its Derivatives
por: Abidin, Mohammad Z., et al.
Publicado: (2018)

Recent Applications of Carbon‐Nitrogen Lyases in Asymmetric Synthesis of Noncanonical Amino Acids and Heterocyclic Compounds
por: Zhang, Jielin, et al.
Publicado: (2020)

Biocatalytic enantioselective hydroaminations enabling synthesis of N-arylalkyl-substituted l-aspartic acids
por: Abidin, Mohammad Z., et al.
Publicado: (2021)

Inhibitors of pantothenate synthetase of Mycobacterium tuberculosis – a medicinal chemist perspective
por: Suresh, Amaroju, et al.
Publicado: (2020)

Mutations in the pantothenate kinase of Plasmodium falciparum confer diverse sensitivity profiles to antiplasmodial pantothenate analogues
por: Tjhin, Erick T., et al.
Publicado: (2018)

Optimization of Inhibitors of Mycobacterium tuberculosis Pantothenate Synthetase Based on Group Efficiency Analysis
por: Hung, Alvin W., et al.
Publicado: (2015)

The Broad Aryl Acid Specificity of the Amide Bond Synthetase McbA Suggests Potential for the Biocatalytic Synthesis of Amides
por: Petchey, Mark, et al.
Publicado: (2018)

Biocatalytic Asymmetric Michael Additions of Nitromethane to α,β-Unsaturated Aldehydes via Enzyme-bound Iminium Ion Intermediates
por: Guo, Chao, et al.
Publicado: (2019)

Biocatalytic Asymmetric Cyclopropanations via Enzyme‐Bound Iminium Ion Intermediates
por: Kunzendorf, Andreas, et al.
Publicado: (2021)

Vitamin in the Crosshairs: Targeting Pantothenate and Coenzyme A Biosynthesis for New Antituberculosis Agents
por: Butman, Hailey S., et al.
Publicado: (2020)

The effect of tumour growth on liver pantothenate, CoA, and fatty acid synthetase activity in the mouse.
por: McAllister, R. A., et al.
Publicado: (1988)

Enantiocomplementary Epoxidation Reactions Catalyzed by an Engineered Cofactor‐Independent Non‐natural Peroxygenase
por: Xu, Guangcai, et al.
Publicado: (2020)

Expanding Water/Base Tolerant Frustrated Lewis Pair Chemistry to Alkylamines Enables Broad Scope Reductive Aminations
por: Fasano, Valerio, et al.
Publicado: (2017)

Benzylic C–H isocyanation/amine coupling sequence enabling high-throughput synthesis of pharmaceutically relevant ureas
por: Suh, Sung-Eun, et al.
Publicado: (2021)

Alanine mutation of the catalytic sites of Pantothenate Synthetase causes distinct conformational changes in the ATP binding region
por: Pandey, Bharati, et al.
Publicado: (2018)

Simple ruthenium-catalyzed reductive amination enables the synthesis of a broad range of primary amines
por: Senthamarai, Thirusangumurugan, et al.
Publicado: (2018)

Enantioselective Aldol Addition of Acetaldehyde to Aromatic Aldehydes Catalyzed by Proline-Based Carboligases
por: Saifuddin, Mohammad, et al.
Publicado: (2020)

Enantioselective Synthesis of Pharmaceutically Active γ-Aminobutyric Acids Using a Tailor-Made Artificial Michaelase in One-Pot Cascade Reactions
por: Biewenga, Lieuwe, et al.
Publicado: (2019)

Broad-Scope Amination of Aryl Sulfamates Catalyzed by a Palladium Phosphine Complex
por: Monti, Andrea, et al.
Publicado: (2023)

A novel heteromeric pantothenate kinase complex in apicomplexan parasites
por: Tjhin, Erick T., et al.
Publicado: (2021)

Compartmentalization of Mammalian Pantothenate Kinases
por: Alfonso-Pecchio, Adolfo, et al.
Publicado: (2012)

Pantothenate kinase-associated neurodegeneration
por: Hundallah, Khalid, et al.
Publicado: (2017)

Structural Basis for the Catalytic Mechanism of Ethylenediamine-N,N′-disuccinic Acid Lyase, a Carbon–Nitrogen Bond-Forming Enzyme with a Broad Substrate Scope
por: Poddar, Harshwardhan, et al.
Publicado: (2018)

THE EFFECTS OF PANTOTHENIC ACID ON RESPIRATORY ACTIVITY
por: Pratt, Ernest F., et al.
Publicado: (1939)

Genetic mutation spectrum of pantothenate kinase-associated neurodegeneration expanded by breakpoint sequencing in pantothenate kinase 2 gene
por: Yang, Dahae, et al.
Publicado: (2022)

Engineered C–N Lyase: Enantioselective Synthesis of Chiral Synthons for Artificial Dipeptide Sweeteners
por: Zhang, Jielin, et al.
Publicado: (2019)

Rhodium-catalyzed oxidative amidation of allylic alcohols and aldehydes: effective conversion of amines and anilines into amides
por: Wu, Zhao, et al.
Publicado: (2016)

Pantothenate kinase-associated neurodegeneration is not a synucleinopathy
por: Li, A, et al.
Publicado: (2013)

Novel pantothenate derivatives for anti-malarial chemotherapy
por: Pett, Helmi E, et al.
Publicado: (2015)

Precision medicine in pantothenate kinase-associated neurodegeneration
por: Álvarez-Córdoba, Mónica, et al.
Publicado: (2019)

Proposed Therapies for Pantothenate-Kinase-Associated Neurodegeneration
por: Jackowski, Suzanne
Publicado: (2019)

Redesigning therapies for pantothenate kinase–associated neurodegeneration
por: Munshi, Muhammad I., et al.
Publicado: (2022)

A broad inhibitor of acyl-acyl carrier protein synthetases
por: Todorinova, Magdalena, et al.
Publicado: (2023)

Novel Compound Heterozygous Mutations in the Pantothenate Kinase 2 Gene in a Korean Patient with Atypical Pantothenate Kinase Associated Neurodegeneration
por: Kim, Sung-Hyouk, et al.
Publicado: (2009)

Enhancing the Peroxygenase Activity of a Cofactor‐Independent Peroxyzyme by Directed Evolution Enabling Gram‐Scale Epoxide Synthesis
por: Sigmund, Marie‐Cathérine, et al.
Publicado: (2022)

Chemo- and Stereoselective Transition-Metal-Free Amination of Amides with Azides
por: Tona, Veronica, et al.
Publicado: (2016)

The PM6-FGC Method: Improved Corrections for Amines and Amides
por: Ríos-García, Martiño, et al.
Publicado: (2022)

One-pot synthesis of amides via the oxidative amidation of aldehydes and amines catalyzed by a copper-MOF
por: Jamalifard, Samira, et al.
Publicado: (2019)

Functional Expression and Characterization of the Highly Promiscuous Lanthipeptide Synthetase SyncM, Enabling the Production of Lanthipeptides with a Broad Range of Ring Topologies
por: Arias-Orozco, Patricia, et al.
Publicado: (2021)

The Influence of Thiamine and Pantothenate Upon Tissue -Sh Levels
por: Calcutt, G.
Publicado: (1961)

Cannot write session to /tmp/vufind_sessions/sess_imf4mm6kbtt9j9f6gpa5ast4p2