PARP Power: A Structural Perspective on PARP1, PARP2, and PARP3 in DNA Damage Repair and Nucleosome Remodelling

Poly (ADP-ribose) polymerases (PARP) 1-3 are well-known multi-domain enzymes, catalysing the covalent modification of proteins, DNA, and themselves. They attach mono- or poly-ADP-ribose to targets using NAD(+) as a substrate. Poly-ADP-ribosylation (PARylation) is central to the important functions o...

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Detalles Bibliográficos
Autores principales: van Beek, Lotte, McClay, Éilís, Patel, Saleha, Schimpl, Marianne, Spagnolo, Laura, Maia de Oliveira, Taiana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8150716/
https://www.ncbi.nlm.nih.gov/pubmed/34066057
http://dx.doi.org/10.3390/ijms22105112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8150716/
https://www.ncbi.nlm.nih.gov/pubmed/34066057
http://dx.doi.org/10.3390/ijms22105112

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