In Vitro Activity of Novel Antifungal Olorofim against Filamentous Fungi and Comparison to Eight Other Antifungal Agents

Olorofim is a novel antifungal drug that belongs to the orotomide drug class which inhibits fungal dihydroorotate dehydrogenase (DHODH), thus halting pyrimidine biosynthesis and ultimately DNA synthesis, cell growth and division. It is being developed at a time when many invasive fungal infections e...

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Detalles Bibliográficos
Autores principales: Georgacopoulos, Ourania, Nunnally, Natalie S., Ransom, Eric M., Law, Derek, Birch, Mike, Lockhart, Shawn R., Berkow, Elizabeth L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8150786/
https://www.ncbi.nlm.nih.gov/pubmed/34065811
http://dx.doi.org/10.3390/jof7050378

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8150786/
https://www.ncbi.nlm.nih.gov/pubmed/34065811
http://dx.doi.org/10.3390/jof7050378

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