Cargando…

Technologies for High-Throughput Identification of Antibiotic Mechanism of Action

There are two main strategies for antibiotic discovery: target-based and phenotypic screening. The latter has been much more successful in delivering first-in-class antibiotics, despite the major bottleneck of delayed Mechanism-of-Action (MOA) identification. Although finding new antimicrobial compo...

Descripción completa

Detalles Bibliográficos
Autores principales:	da Cunha, Bernardo Ribeiro, Zoio, Paulo, Fonseca, Luís P., Calado, Cecília R. C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151116/ https://www.ncbi.nlm.nih.gov/pubmed/34065815 http://dx.doi.org/10.3390/antibiotics10050565

Ejemplares similares

Metabolic Fingerprinting with Fourier-Transform Infrared (FTIR) Spectroscopy: Towards a High-Throughput Screening Assay for Antibiotic Discovery and Mechanism-of-Action Elucidation
por: Ribeiro da Cunha, Bernardo, et al.
Publicado: (2020)

Antibiotic Discovery: Where Have We Come from, Where Do We Go?
por: Ribeiro da Cunha, Bernardo, et al.
Publicado: (2019)

A Simple, Label-Free, and High-Throughput Method to Evaluate the Epigallocatechin-3-Gallate Impact in Plasma Molecular Profile
por: Araújo, Rúben, et al.
Publicado: (2020)

Skin-on-a-Chip Technology: Microengineering Physiologically Relevant In Vitro Skin Models
por: Zoio, Patrícia, et al.
Publicado: (2022)

Infection Biomarkers Based on Metabolomics
por: Araújo, Rúben, et al.
Publicado: (2022)

Identification of Compounds That Interfere with High‐Throughput Screening Assay Technologies
por: David, Laurianne, et al.
Publicado: (2019)

Greatest Hits—Innovative Technologies for High Throughput Identification of Bispecific Antibodies
por: Hofmann, Tim, et al.
Publicado: (2020)

High-throughput phenotyping allows the selection of soybean genotypes for earliness and high grain yield
por: Santana, Dthenifer Cordeiro, et al.
Publicado: (2022)

High-Throughput Carbohydrate Microarray Technology
por: Wang, Denong, et al.
Publicado: (2007)

High-Throughput Screening of Biodiversity for Antibiotic Discovery
por: Terekhov, S. S., et al.
Publicado: (2018)

High-throughput identification and rational design of synergistic small-molecule pairs for combating and bypassing antibiotic resistance
por: Wambaugh, Morgan A., et al.
Publicado: (2017)

The Identification of Microdeletion and Reciprocal Microduplication in 22q11.2 Using High-Resolution CMA Technology
por: Leite, Ana Julia Cunha, et al.
Publicado: (2016)

Empirical assessment of sequencing errors for high throughput pyrosequencing data
por: da Fonseca, Paulo GS, et al.
Publicado: (2013)

Analysis of cancer metabolism with high-throughput technologies
por: Markovets, Aleksandra A, et al.
Publicado: (2011)

Identification and correction of spatial bias are essential for obtaining quality data in high-throughput screening technologies
por: Mazoure, Bogdan, et al.
Publicado: (2017)

Application of High-Throughput Sequencing Technology in the Pathogen Identification of Diverse Infectious Diseases in Nephrology Departments
por: Wang, Yujuan, et al.
Publicado: (2022)

Yeast Double Transporter Gene Deletion Library for Identification of Xenobiotic Carriers in Low or High Throughput
por: Almeida, Ludimila Dias, et al.
Publicado: (2021)

The Mechanisms of Action of Ribosome-Targeting Peptide Antibiotics
por: Polikanov, Yury S., et al.
Publicado: (2018)

Application of Omics Technologies for Evaluation of Antibacterial Mechanisms of Action of Plant-Derived Products
por: dos Santos, Bruno S., et al.
Publicado: (2016)

Total synthesis and mechanism of action of the antibiotic armeniaspirol A
por: Arisetti, Nanaji, et al.
Publicado: (2021)

Combining High‐Throughput Synthesis and High‐Throughput Protein Crystallography for Accelerated Hit Identification
por: Sutanto, Fandi, et al.
Publicado: (2021)

High-throughput methods for identification of protein-protein interactions involving short linear motifs
por: Blikstad, Cecilia, et al.
Publicado: (2015)

Adipogenic Transcriptome Profiling Using High Throughput Technologies
por: Basu, Urmila, et al.
Publicado: (2013)

The Application of High-Throughput Technologies for the Study of Microbiome and Cancer
por: Wei, Lu Qi, et al.
Publicado: (2021)

Three Grand Challenges in High Throughput Omics Technologies
por: Suravajhala, Prashanth, et al.
Publicado: (2022)

Mechanism-of-Action Classification of Antibiotics by Global Transcriptome Profiling
por: O’Rourke, Aubrie, et al.
Publicado: (2020)

Identification and characterization of microRNAs in Phaseolus vulgaris by high-throughput sequencing
por: Peláez, Pablo, et al.
Publicado: (2012)

Plasmid ATLAS: plasmid visual analytics and identification in high-throughput sequencing data
por: Jesus, Tiago F, et al.
Publicado: (2019)

Discovery in Genetic Skin Disease: The Impact of High Throughput Genetic Technologies
por: Maruthappu, Thiviyani, et al.
Publicado: (2014)

Plasma versus Serum Analysis by FTIR Spectroscopy to Capture the Human Physiological State
por: Araújo, Rúben, et al.
Publicado: (2022)

Nurseped: educational technology for safety in the management of intravenous antibiotics in pediatrics *
por: Alves, Amanda Paiva Bernardes, et al.
Publicado: (2023)

Luminex and Other Multiplex High Throughput Technologies for the Identification of, and Host Response to, Environmental Triggers of Type 1 Diabetes
por: Purohit, Sharad, et al.
Publicado: (2015)

High Throughput Approaches to Unravel the Mechanism of Action of a New Vanadium-Based Compound against Trypanosoma cruzi
por: Mosquillo, M. Florencia, et al.
Publicado: (2020)

Action and resistance mechanisms of antibiotics: A guide for clinicians
por: Kapoor, Garima, et al.
Publicado: (2017)

Quantitative High-Throughput Screening Methods Designed for Identification of Bacterial Biocontrol Strains with Antifungal Properties
por: Kjeldgaard, Bodil, et al.
Publicado: (2022)

Data structures and compression algorithms for high-throughput sequencing technologies
por: Daily, Kenny, et al.
Publicado: (2010)

Cell Microarray Technologies for High-Throughput Cell-Based Biosensors
por: Hong, Hye Jin, et al.
Publicado: (2017)

Assessing Illumina technology for the high-throughput sequencing of bacteriophage genomes
por: Rihtman, Branko, et al.
Publicado: (2016)

Implementation of High-Throughput Sequencing (HTS) in Aptamer Selection Technology
por: Komarova, Natalia, et al.
Publicado: (2020)

Cutaneous Melanoma Classification: The Importance of High-Throughput Genomic Technologies
por: Scatena, Cristian, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_cstr82ocb7epape12nk2t5tort