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Protective Mechanism of Edible Food Plants against Alcoholic Liver Disease with Special Mention to Polyphenolic Compounds

Alcoholic liver disease (ALD) is one type of liver disease, causing a global healthcare problem and mortality. The liver undergoes tissue damage by chronic alcohol consumption because it is the main site for metabolism of ethanol. Chronic alcohol exposure progresses from alcoholic fatty liver (AFL)...

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Autores principales: Zhao, Liang, Mehmood, Arshad, Yuan, Dongdong, Usman, Muhammad, Murtaza, Mian Anjum, Yaqoob, Sanabil, Wang, Chengtao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151346/
https://www.ncbi.nlm.nih.gov/pubmed/34064981
http://dx.doi.org/10.3390/nu13051612
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author Zhao, Liang
Mehmood, Arshad
Yuan, Dongdong
Usman, Muhammad
Murtaza, Mian Anjum
Yaqoob, Sanabil
Wang, Chengtao
author_facet Zhao, Liang
Mehmood, Arshad
Yuan, Dongdong
Usman, Muhammad
Murtaza, Mian Anjum
Yaqoob, Sanabil
Wang, Chengtao
author_sort Zhao, Liang
collection PubMed
description Alcoholic liver disease (ALD) is one type of liver disease, causing a global healthcare problem and mortality. The liver undergoes tissue damage by chronic alcohol consumption because it is the main site for metabolism of ethanol. Chronic alcohol exposure progresses from alcoholic fatty liver (AFL) to alcoholic steatohepatitis (ASH), which further lead to fibrosis, cirrhosis, and even hepatocellular cancer. Therapeutic interventions to combat ALD are very limited such as use of corticosteroids. However, these therapeutic drugs are not effective for long-term usage. Therefore, additional effective and safe therapies to cope with ALD are urgently needed. Previous studies confirmed that edible food plants and their bioactive compounds exert a protective effect against ALD. In this review article, we summarized the hepatoprotective potential of edible food plants and their bioactive compounds. The underlying mechanism for the prevention of ALD by edible food plants was as follows: anti-oxidation, anti-inflammation, lipid regulation, inhibition of apoptosis, gut microbiota composition modulation, and anti-fibrosis.
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spelling pubmed-81513462021-05-27 Protective Mechanism of Edible Food Plants against Alcoholic Liver Disease with Special Mention to Polyphenolic Compounds Zhao, Liang Mehmood, Arshad Yuan, Dongdong Usman, Muhammad Murtaza, Mian Anjum Yaqoob, Sanabil Wang, Chengtao Nutrients Review Alcoholic liver disease (ALD) is one type of liver disease, causing a global healthcare problem and mortality. The liver undergoes tissue damage by chronic alcohol consumption because it is the main site for metabolism of ethanol. Chronic alcohol exposure progresses from alcoholic fatty liver (AFL) to alcoholic steatohepatitis (ASH), which further lead to fibrosis, cirrhosis, and even hepatocellular cancer. Therapeutic interventions to combat ALD are very limited such as use of corticosteroids. However, these therapeutic drugs are not effective for long-term usage. Therefore, additional effective and safe therapies to cope with ALD are urgently needed. Previous studies confirmed that edible food plants and their bioactive compounds exert a protective effect against ALD. In this review article, we summarized the hepatoprotective potential of edible food plants and their bioactive compounds. The underlying mechanism for the prevention of ALD by edible food plants was as follows: anti-oxidation, anti-inflammation, lipid regulation, inhibition of apoptosis, gut microbiota composition modulation, and anti-fibrosis. MDPI 2021-05-11 /pmc/articles/PMC8151346/ /pubmed/34064981 http://dx.doi.org/10.3390/nu13051612 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhao, Liang
Mehmood, Arshad
Yuan, Dongdong
Usman, Muhammad
Murtaza, Mian Anjum
Yaqoob, Sanabil
Wang, Chengtao
Protective Mechanism of Edible Food Plants against Alcoholic Liver Disease with Special Mention to Polyphenolic Compounds
title Protective Mechanism of Edible Food Plants against Alcoholic Liver Disease with Special Mention to Polyphenolic Compounds
title_full Protective Mechanism of Edible Food Plants against Alcoholic Liver Disease with Special Mention to Polyphenolic Compounds
title_fullStr Protective Mechanism of Edible Food Plants against Alcoholic Liver Disease with Special Mention to Polyphenolic Compounds
title_full_unstemmed Protective Mechanism of Edible Food Plants against Alcoholic Liver Disease with Special Mention to Polyphenolic Compounds
title_short Protective Mechanism of Edible Food Plants against Alcoholic Liver Disease with Special Mention to Polyphenolic Compounds
title_sort protective mechanism of edible food plants against alcoholic liver disease with special mention to polyphenolic compounds
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151346/
https://www.ncbi.nlm.nih.gov/pubmed/34064981
http://dx.doi.org/10.3390/nu13051612
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