Development of Novel Indole-Based Bifunctional Aldose Reductase Inhibitors/Antioxidants as Promising Drugs for the Treatment of Diabetic Complications

Aldose reductase (AR, ALR2), the first enzyme of the polyol pathway, is implicated in the pathophysiology of diabetic complications. Aldose reductase inhibitors (ARIs) thus present a promising therapeutic approach to treat a wide array of diabetic complications. Moreover, a therapeutic potential of...

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Detalles Bibliográficos
Autores principales: Kovacikova, Lucia, Prnova, Marta Soltesova, Majekova, Magdalena, Bohac, Andrej, Karasu, Cimen, Stefek, Milan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151378/
https://www.ncbi.nlm.nih.gov/pubmed/34066081
http://dx.doi.org/10.3390/molecules26102867

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151378/
https://www.ncbi.nlm.nih.gov/pubmed/34066081
http://dx.doi.org/10.3390/molecules26102867

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