Cargando…
Effect of F16-Betulin Conjugate on Mitochondrial Membranes and Its Role in Cell Death Initiation
This work demonstrates the effects of a newly synthesized conjugate of the plant triterpenoid betulin and the penetrating cation F16 used for mitochondrial targeting. The resulting F16-betulin conjugate revealed a mitochondria-targeted effect, decreasing the mitochondrial potential and inducing supe...
Autores principales: | Dubinin, Mikhail V., Semenova, Alena A., Nedopekina, Darya A., Davletshin, Eldar V., Spivak, Anna Yu., Belosludtsev, Konstantin N. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151401/ https://www.ncbi.nlm.nih.gov/pubmed/34068772 http://dx.doi.org/10.3390/membranes11050352 |
Ejemplares similares
-
Comparative Study of Cytotoxic and Membranotropic Properties of Betulinic Acid-F16 Conjugate on Breast Adenocarcinoma Cells (MCF-7) and Primary Human Fibroblasts
por: Belosludtsev, Konstantin N., et al.
Publicado: (2022) -
Conjugation of Triterpenic Acids of Ursane and Oleanane Types with Mitochondria-Targeting Cation F16 Synergistically Enhanced Their Cytotoxicity against Tumor Cells
por: Dubinin, Mikhail V., et al.
Publicado: (2023) -
Conjugation of Natural Triterpenic Acids with Delocalized Lipophilic Cations: Selective Targeting Cancer Cell Mitochondria
por: Spivak, Anna Yu., et al.
Publicado: (2021) -
Mitochondria-targeted betulinic and ursolic acid derivatives: synthesis and anticancer activity
por: Nedopekina, Darya A., et al.
Publicado: (2017) -
S-15176 Difumarate Salt Can Impair Mitochondrial Function through Inhibition of the Respiratory Complex III and Permeabilization of the Inner Mitochondrial Membrane
por: Belosludtseva, Natalia V., et al.
Publicado: (2022)