Hybrid Cyclobutane/Proline-Containing Peptidomimetics: The Conformational Constraint Influences Their Cell-Penetration Ability

A new family of hybrid β,γ-peptidomimetics consisting of a repetitive unit formed by a chiral cyclobutane-containing trans-β-amino acid plus a N(α)-functionalized trans-γ-amino-l-proline joined in alternation were synthesized and evaluated as cell penetrating peptides (CPP). They lack toxicity on th...

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Detalles Bibliográficos
Autores principales: Illa, Ona, Ospina, Jimena, Sánchez-Aparicio, José-Emilio, Pulido, Ximena, Abengozar, María Ángeles, Gaztelumendi, Nerea, Carbajo, Daniel, Nogués, Carme, Rivas, Luis, Maréchal, Jean-Didier, Royo, Miriam, Ortuño, Rosa M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151717/
https://www.ncbi.nlm.nih.gov/pubmed/34065025
http://dx.doi.org/10.3390/ijms22105092

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151717/
https://www.ncbi.nlm.nih.gov/pubmed/34065025
http://dx.doi.org/10.3390/ijms22105092

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